Tuberculosis-Associated MicroRNAs: From Pathogenesis to Disease Biomarkers

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2020 Sep 29

PMID 32987746

Citations 44

Authors

Alessandro Sinigaglia

Elektra Peta

Silvia Riccetti

Seshasailam Venkateswaran

Riccardo Manganelli

Luisa Barzon

Affiliations

Soon will be listed here.

Abstract

Tuberculosis (TB) caused by is one of the most lethal infectious diseases with estimates of approximately 1.4 million human deaths in 2018. has a well-established ability to circumvent the host immune system to ensure its intracellular survival and persistence in the host. Mechanisms include subversion of expression of key microRNAs (miRNAs) involved in the regulation of host innate and adaptive immune response against . Several studies have reported differential expression of miRNAs during active TB and latent tuberculosis infection (LTBI), suggesting their potential use as biomarkers of disease progression and response to anti-TB therapy. This review focused on the miRNAs involved in TB pathogenesis and on the mechanism through which miRNAs induced during TB modulate cell antimicrobial responses. An attentive study of the recent literature identifies a group of miRNAs, which are differentially expressed in active TB vs. LTBI or vs. treated TB and can be proposed as candidate biomarkers.

Citing Articles

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