A New Thiopeptide Antibiotic, Micrococcin P3, from a Marine-Derived Strain of the Bacterium

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Sep 29

PMID 32987657

Citations 4

Authors

Weihong Wang

Kyu-Hyung Park

Jusung Lee

Eunseok Oh

Chanyoon Park

Eunmo Kang

Juni Lee

Heonjoong Kang

Affiliations

Soon will be listed here.

Abstract

A new thiopeptide (micrococcin P3, ) and a known one (micrococcin P1, ) were isolated from the culture broth of a marine-derived strain of . The structures of both compounds were elucidated using spectroscopic methods, including extensive 1D and 2D NMR analysis, high resolution mass spectrometry (HRMS), and tandem mass spectrometry. Both compounds exhibited potent antibacterial activities against Gram-positive strains with minimum inhibitory concentration (MIC) values of 0.05-0.8 μg/mL and did not show cytotoxicity in the MTT assay up to a concentration of 10 μM. This study adds a new promising member, micrococcin P3, to the family of thiopeptide antibiotics, which shows potential for the development of new antibiotics targeting Gram-positive bacteria.

Citing Articles

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