Physical Activity Versus Sclerostin and Interleukin 6 Concentration in Patients Receiving Renal Replacement Therapy by Hemodialysis

Overview

Journal Risk Manag Healthc Policy

Publisher Dove Medical Press

Specialty Public Health

Date 2020 Sep 28

PMID 32982505

Citations 5

Authors

Agnieszka Turon-Skrzypinska

Grazyna Dutkiewicz

Malgorzata Marchelek-Mysliwiec

Aleksandra Ryl

Violetta Dziedziejko

Krzysztof Safranow

Kazimierz Ciechanowski

Iwona Rotter

Affiliations

Soon will be listed here.

Abstract

Introduction: Chronic kidney disease and renal replacement therapy are associated with reduced motor activity, which may result in the presence of mineral bone disorders and an increase in inflammation markers. The aim of the study was to assess the relationship between the performance of daily physical activity, expressed in the number of steps performed by patients undergoing hemodialysis and the concentration of selected biochemical parameters (SCL, IL-6).

Patients And Methods: The study group (B) involved 33 patients aged 59.8 ± 9.8 years from the dialysis station at the Department of Nephrology, Transplantology and Internal Medicine PUM. In group B, interventions considering an increase in physical activity expressed in the number of steps were introduced. Group C consisted of 30 people aged 54.9 (9.37), with GFR over 60 mL/min/1.73m. Physical activity was measured with pedometers. Anthropometric and biochemical parameters were assessed at baseline, after the third and sixth month of the study. Descriptive statistics, intergroup comparisons using Mann-Whitney U test and Spearman correlation analysis were performed. The level of significance was set at p≤0.005.

Results: A relationship between IL-6 concentration and the number of steps in group B after three months of intervention was demonstrated. In group C, the concentration of SCL and IL-6 decreased with the increase in the number of steps taken. Only in group C the waist circumference decreased with the increase of the number of steps performed.

Conclusion: Patients receiving renal replacement therapy by hemodialysis showed significantly lower physical activity compared to people without kidney disease. Performing bigger number of steps can lower interleukin 6 levels in hemodialysis patients.

Citing Articles

Analysis of changes in PCSK9 and TNF-α concentrations in response to physical exercises using virtual reality in patients in the fifth stage of chronic kidney disease undergoing hemodialysis.

Turon-Skrzypinska A, Minko A, Ryl A, Cymbaluk-Ploska A, Domanski M, Ciechanowski K BMC Nephrol. 2025; 26(1):1.

PMID: 39743553 PMC: 11694471. DOI: 10.1186/s12882-024-03917-z.

Impact of Effectiveness of Physical Activity in a Virtual Environment on the Regulation of Sclerostin and Interleukin 6 Levels in Haemodialysis Patients.

Turon-Skrzypinska A, Minko A, Ryl A, Mankowska K, Ciechanowski K, Bereda Z J Clin Med. 2024; 13(8).

PMID: 38673595 PMC: 11051331. DOI: 10.3390/jcm13082321.

Interventions to increase physical activity level in patients with whole spectrum chronic kidney disease: a systematic review and meta-analysis.

Zhang H, Wang H, Huang L, Bai Y, Zhang F Ren Fail. 2023; 45(2):2255677.

PMID: 37724555 PMC: 10512821. DOI: 10.1080/0886022X.2023.2255677.

Does Exercising with the Use of Virtual Reality during Haemodialysis Have an Impact on Plasma Levels of Interleukin 1β, Interleukin 6, and Interleukin 8?.

Turon-Skrzypinska A, Rotter I, Przybycinski J, Szylinska A, Minko A, Ciechanowski K J Clin Med. 2023; 12(16).

PMID: 37629400 PMC: 10456086. DOI: 10.3390/jcm12165358.

Obesity phenotypes are, in part, associated with physical activity in diabetic hemodialysis patients.

Matos B, da Costa Rosa C, Ribeiro H, Marcos N, Losilla M, Monteiro H Int Urol Nephrol. 2021; 54(7):1751-1759.

PMID: 34816362 DOI: 10.1007/s11255-021-03060-w.

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