The Immunoglobulins of Cartilaginous Fishes

Overview

Journal Dev Comp Immunol

Specialty Allergy & Immunology

Date 2020 Sep 26

PMID 32979434

Citations 10

Authors

Hanover Matz

Danish Munir

James Logue

Helen Dooley

Affiliations

Soon will be listed here.

Abstract

Cartilaginous fishes, comprising the chimeras, sharks, skates, and rays, split from the common ancestor with other jawed vertebrates approx. 450 million years ago. Being the oldest extant taxonomic group to possess an immunoglobulin (Ig)-based adaptive immune system, examination of this group has taught us much about the evolution of adaptive immunity, as well as the conserved and taxon-specific characteristics of Igs. Significant progress has been made analyzing sequences from numerous genomic and transcriptomic data sets. These findings have been supported by additional functional studies characterizing the Igs and humoral response of sharks and their relatives. This review will summarize what we have learned about the genomic organization, protein structure, and in vivo function of these Ig isotypes in cartilaginous fishes and highlight the areas where our knowledge is still lacking.

Citing Articles

Expression Analysis of Heavy-Chain-Only Antibodies in Cloudy Catshark and Japanese Bullhead Shark.

Uemura R, Tanimura S, Yamaguchi N, Kuroiwa R, Andres Tsutsumi G, Fujikawa T Mar Drugs. 2025; 23(1).

PMID: 39852530 PMC: 11767079. DOI: 10.3390/md23010028.

Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes.

Wang H, Chen J, Li Y, Zhang X, Liu X, Lu Y Nat Commun. 2024; 15(1):7627.

PMID: 39227568 PMC: 11372145. DOI: 10.1038/s41467-024-51761-4.

Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1.

Malinge P, Chauchet X, Bourguignon J, Bosson N, Calloud S, Bautzova T MAbs. 2024; 16(1):2362432.

PMID: 38849989 PMC: 11164222. DOI: 10.1080/19420862.2024.2362432.

450 million years in the making: mapping the evolutionary foundations of germinal centers.

Matz H, Dooley H Front Immunol. 2023; 14:1245704.

PMID: 37638014 PMC: 10450919. DOI: 10.3389/fimmu.2023.1245704.

Evolution of the Immunoglobulin Isotypes-Variations of Biophysical Properties among Animal Classes.

Pomarici N, Cacciato R, Kokot J, Fernandez-Quintero M, Liedl K Biomolecules. 2023; 13(5).

PMID: 37238671 PMC: 10216798. DOI: 10.3390/biom13050801.

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