Precursors to Regulatory Peptides: Their Proteolytic Processing
Overview
Authors
Affiliations
Precursors to regulatory peptides undergo maturation processes which include proteolytic processing. The enzymes involved in this process remove the hydrophobic peptide located at the amino-terminus of the precursor. Endoprotease cleavage also occurs at single and two adjacent basic residues, this is followed by a removal of basic residues located at the C-terminus of the peptides by a carboxypeptidase-like enzyme.
Siekhaus D, Fuller R J Neurosci. 1999; 19(16):6942-54.
PMID: 10436051 PMC: 6782853.
Nakayama K Biochem J. 1998; 327 ( Pt 3):625-35.
PMID: 9599222 PMC: 1218878. DOI: 10.1042/bj3270625.
Otsuka Y, Ojika K Neurochem Res. 1996; 21(3):369-76.
PMID: 9139244 DOI: 10.1007/BF02531654.
Zumbrunn A, Stone S, Shaw E Biochem J. 1988; 256(3):989-94.
PMID: 3223967 PMC: 1135513. DOI: 10.1042/bj2560989.
Curry W, Johnston C, Hutton J, Arden S, Rutherford N, Shaw C Histochemistry. 1991; 96(6):531-8.
PMID: 1769862 DOI: 10.1007/BF00267079.