» Articles » PMID: 3297766

Precursors to Regulatory Peptides: Their Proteolytic Processing

Overview
Journal Experientia
Specialty Science
Date 1987 Jul 15
PMID 3297766
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Precursors to regulatory peptides undergo maturation processes which include proteolytic processing. The enzymes involved in this process remove the hydrophobic peptide located at the amino-terminus of the precursor. Endoprotease cleavage also occurs at single and two adjacent basic residues, this is followed by a removal of basic residues located at the C-terminus of the peptides by a carboxypeptidase-like enzyme.

Citing Articles

A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior.

Siekhaus D, Fuller R J Neurosci. 1999; 19(16):6942-54.

PMID: 10436051 PMC: 6782853.


Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins.

Nakayama K Biochem J. 1998; 327 ( Pt 3):625-35.

PMID: 9599222 PMC: 1218878. DOI: 10.1042/bj3270625.


Demonstration and characterization of hippocampal cholinergic neurostimulating peptide (HCNP) processing enzyme activity in rat hippocampus.

Otsuka Y, Ojika K Neurochem Res. 1996; 21(3):369-76.

PMID: 9139244 DOI: 10.1007/BF02531654.


The synthesis and properties of peptidylmethylsulphonium salts with two cationic residues as potential inhibitors of prohormone processing.

Zumbrunn A, Stone S, Shaw E Biochem J. 1988; 256(3):989-94.

PMID: 3223967 PMC: 1135513. DOI: 10.1042/bj2560989.


The tissue distribution of rat chromogranin A-derived peptides: evidence for differential tissue processing from sequence specific antisera.

Curry W, Johnston C, Hutton J, Arden S, Rutherford N, Shaw C Histochemistry. 1991; 96(6):531-8.

PMID: 1769862 DOI: 10.1007/BF00267079.


References
1.
Supattapone S, Fricker L, Snyder S . Purification and characterization of a membrane-bound enkephalin-forming carboxypeptidase, "enkephalin convertase". J Neurochem. 1984; 42(4):1017-23. DOI: 10.1111/j.1471-4159.1984.tb12705.x. View

2.
Douglass J, Civelli O, Herbert E . Polyprotein gene expression: generation of diversity of neuroendocrine peptides. Annu Rev Biochem. 1984; 53:665-715. DOI: 10.1146/annurev.bi.53.070184.003313. View

3.
Fletcher D, Noe B, BAUER G, Quigley J . Characterization of the conversion of a somatostatin precursor to somatostatin by islet secretory granules. Diabetes. 1980; 29(8):593-9. DOI: 10.2337/diab.29.8.593. View

4.
Fricker L, Snyder S . Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase. J Biol Chem. 1983; 258(18):10950-5. View

5.
McDonald J, Greiner F, BAUER G, Elde R, Noe B . Separate cell types that express two different forms of somatostatin in anglerfish islets can be immunohistochemically differentiated. J Histochem Cytochem. 1987; 35(2):155-62. DOI: 10.1177/35.2.2878951. View