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» Articles » PMID: 32976531

The Changes of the Peripheral CD4+ Lymphocytes and Inflammatory Cytokines in Patients with COVID-19

Overview
Journal PLoS One
Specialties General Medicine
Science
Date 2020 Sep 25
PMID 32976531
Citations 20
Authors
Hua-Bao Sun
Yi-Ming Zhang
Li-Gui Huang
Qi-Nan Lai
Qun Mo
Xin-Zhou Ye
Tao Wang
Zhong-Zhen Zhu
Xiao-Lin Lv
Yan-Ji Luo
Shi-Ding Gao
Jin-Song Xu
Hao-Hao Zhu
Ting Li
Zhan-Ke Wang
Affiliations
Soon will be listed here.
Abstract

To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.

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