Solanine Attenuates Hepatocarcinoma Migration and Invasion Induced by Acetylcholine

Overview

Journal Integr Cancer Ther

Publisher Sage Publications

Specialties Oncology
Pharmacology

Date 2020 Sep 25

PMID 32975458

Citations 6

Authors

Liang-Tzung Lin

Chen-Yen Choong

Chen-Jei Tai

Affiliations

Soon will be listed here.

Abstract

Aim: Evidence has provided an explanation of the correlation between the nervous system and the tumor microenvironment. Neurotransmitters may be involved in different aspects of cancer progression. The glycoalkaloid solanine has been reported to suppress neural signaling pathways and exists in numerous plants, including , which have been demonstrated to inhibit cancer cell proliferation.

Methods: We evaluated the potentials of solanine on inhibiting acetylcholine-induced cell proliferation and migration in hepatocellular carcinoma cells.

Results: The results indicated that solanine markedly attenuated cell proliferation and migration via inhibiting epithelial-mesenchymal transition and matrix metalloproteinases in acetylcholine-treated Hep G2 cells. In addition, exosomes derived from acetylcholine-treated Hep G2 cells were isolated, and solanine showed inhibiting effects of extrahepatic metastasis on blocking cell proliferation in exosome-treated A549 lung carcinoma cells through regulating microRNA-21 expression.

Conclusion: Solanine has strong potential for application in integrative cancer therapy.

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Tang X, Guo Y, Zhang S, Wang X, Teng Y, Jin Q Drug Des Devel Ther. 2023; 17:389-402.

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References

Gebhardt C . The historical role of species from the Solanaceae plant family in genetic research. Theor Appl Genet. 2016; 129(12):2281-2294. PMC: 5121179. DOI: 10.1007/s00122-016-2804-1. View

Mao B, Xiao H, Zhang Z, Wang D, Wang G . MicroRNA‑21 regulates the expression of BTG2 in HepG2 liver cancer cells. Mol Med Rep. 2015; 12(4):4917-24. PMC: 4581755. DOI: 10.3892/mmr.2015.4051. View

Friedman J, Richbart S, Merritt J, Brown K, Nolan N, Akers A . Acetylcholine signaling system in progression of lung cancers. Pharmacol Ther. 2018; 194:222-254. PMC: 6348061. DOI: 10.1016/j.pharmthera.2018.10.002. View

Egleton R, Brown K, Dasgupta P . Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis. Trends Pharmacol Sci. 2008; 29(3):151-8. DOI: 10.1016/j.tips.2007.12.006. View

Yan L, Huang X, Shao Q, Huang M, Deng L, Wu Q . MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA. 2008; 14(11):2348-60. PMC: 2578865. DOI: 10.1261/rna.1034808. View

Wang C, Lin Y, Tai C, Wang C, Chang Y, Choong C . Integrated Treatment of Aqueous Extract of Solanum nigrum-Potentiated Cisplatin- and Doxorubicin-Induced Cytotoxicity in Human Hepatocellular Carcinoma Cells. Evid Based Complement Alternat Med. 2015; 2015:675270. PMC: 4499398. DOI: 10.1155/2015/675270. View

Zhang S, Zeng Z, Tang Z, Sun J, Cheng J, Liu R . Prognostic analysis of pulmonary metastases from hepatocellular carcinoma. Hepatol Int. 2009; 2(2):237-43. PMC: 2716849. DOI: 10.1007/s12072-008-9052-7. View

Zhan J, Jiao D, Wang Y, Song J, Wu J, Wu L . Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti-lung cancer cell invasion. Thorac Cancer. 2017; 8(5):461-470. PMC: 5582578. DOI: 10.1111/1759-7714.12467. View

Zhang B, Lu L, Zhang X, Ye W, Wu J, Xi Q . Hsa-miR-132 regulates apoptosis in non-small cell lung cancer independent of acetylcholinesterase. J Mol Neurosci. 2013; 53(3):335-44. DOI: 10.1007/s12031-013-0136-z. View

10.

Lu R, Fan C, Shangguan W, Liu Y, Li Y, Shang Y . Neurons generated from carcinoma stem cells support cancer progression. Signal Transduct Target Ther. 2017; 2:16036. PMC: 5657421. DOI: 10.1038/sigtrans.2016.36. View

11.

Chernyavsky A, Shchepotin I, Grando S . Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors. Int Immunopharmacol. 2015; 29(1):36-44. DOI: 10.1016/j.intimp.2015.05.033. View

12.

Menter D, Herrmann J, Nicolson G . The role of trophic factors and autocrine/paracrine growth factors in brain metastasis. Clin Exp Metastasis. 1995; 13(2):67-88. DOI: 10.1007/BF00133612. View

13.

Okada Y, Eibl G, Guha S, Duffy J, Reber H, Hines O . Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis. 2004; 21(4):285-92. DOI: 10.1023/b:clin.0000046131.24625.54. View

14.

Ma L, Teruya-Feldstein J, Weinberg R . Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007; 449(7163):682-8. DOI: 10.1038/nature06174. View

15.

Arias H, Richards V, Ng D, Ghafoori M, Le V, Mousa S . Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int J Biochem Cell Biol. 2009; 41(7):1441-51. DOI: 10.1016/j.biocel.2009.01.013. View

16.

Tai C, Wang C, Chang Y, Lin C, Tai C . Aqueous Extract of Solanum nigrum Leaf Activates Autophagic Cell Death and Enhances Docetaxel-Induced Cytotoxicity in Human Endometrial Carcinoma Cells. Evid Based Complement Alternat Med. 2013; 2012:859185. PMC: 3526186. DOI: 10.1155/2012/859185. View

17.

Yang H, Liu C, Zhou R, Yao J, Li X, Shen Y . Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability. Oncotarget. 2016; 7(28):44630-44643. PMC: 5190124. DOI: 10.18632/oncotarget.10134. View

18.

Azuma H, Inamoto T, Sakamoto T, Kiyama S, Ubai T, Shinohara Y . Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism. Cancer Res. 2003; 63(23):8090-6. View

19.

Saloman J, Albers K, Rhim A, Davis B . Can Stopping Nerves, Stop Cancer?. Trends Neurosci. 2016; 39(12):880-889. PMC: 5148708. DOI: 10.1016/j.tins.2016.10.002. View

20.

Improgo M, Scofield M, Tapper A, Gardner P . The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog Neurobiol. 2010; 92(2):212-26. PMC: 2939268. DOI: 10.1016/j.pneurobio.2010.05.003. View