Infectious Complications in Neonatal Transfusion: Narrative Review and Personal Contribution

Overview

Journal Transfus Apher Sci

Specialty Hematology

Date 2020 Sep 25

PMID 32972859

Citations 4

Authors

Maria Bianchi

Nicoletta Orlando

Caterina Giovanna Valentini

Patrizia Papacci

Giovanni Vento

Luciana Teofili

Affiliations

Soon will be listed here.

Abstract

Neonates and prematures are among the most transfused categories of patients. Adverse reactions due to transfusions, such as transfusion-transmitted infections, can affect the rest of their lives. In this systematic review, we revised the literature concerning transfusion-transmitted infection in neonates. We reported case-reports and case-series previously published and we integrated these data with our experience at local neonatal intensive care unit. Moreover, we illustrated strategies for mitigating transfusion-transmitted infections, including donor selection and testing, pathogen inactivation technologies and combined approaches, as for Cytomegalovirus infection, integrating leukoreduction and identification of seronegative donors.

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