Understanding the Influence of Experimental Factors on Bio-interactions of Nanoparticles: Towards Improving Correlation Between in Vitro and in Vivo Studies

Overview

Journal Arch Biochem Biophys

Publisher Elsevier

Specialties Biochemistry
Biophysics

Date 2020 Sep 24

PMID 32971033

Citations 7

Authors

Pavithra Natarajan

John M Tomich

Affiliations

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Abstract

Bionanotechnology has developed rapidly over the past two decades, owing to the extensive and versatile, functionalities and applicability of nanoparticles (NPs). Fifty-one nanomedicines have been approved by FDA since 1995, out of the many NPs based formulations developed to date. The general conformation of NPs consists of a core with ligands coating their surface, that stabilizes them and provides them with added functionalities. The physicochemical properties, especially the surface composition of NPs influence their bio-interactions to a large extent. This review discusses recent studies that help understand the nano-bio interactions of iron oxide and gold NPs with different surface compositions. We discuss the influence of the experimental factors on the outcome of the studies and, thus, the importance of standardization in the field of nanotechnology. Recent studies suggest that with careful selection of experimental parameters, it is possible to improve the positive correlation between in vitro and in vivo studies. This provides a fundamental understanding of the NPs which helps in assessing their potential toxic side effects and may aid in manipulating them further to improve their biocompatibility and biosafety.

Citing Articles

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References

Nash J, Tucker T, Therriault W, Yingling Y . Binding of single stranded nucleic acids to cationic ligand functionalized gold nanoparticles. Biointerphases. 2016; 11(4):04B305. DOI: 10.1116/1.4966653. View

Mulvaney P, Weiss P . Have Nanoscience and Nanotechnology Delivered?. ACS Nano. 2016; 10(8):7225-6. DOI: 10.1021/acsnano.6b05344. View

Sahay G, Alakhova D, Kabanov A . Endocytosis of nanomedicines. J Control Release. 2010; 145(3):182-95. PMC: 2902597. DOI: 10.1016/j.jconrel.2010.01.036. View

Farokhzad O, Langer R . Impact of nanotechnology on drug delivery. ACS Nano. 2009; 3(1):16-20. DOI: 10.1021/nn900002m. View

Feng Q, Liu Y, Huang J, Chen K, Huang J, Xiao K . Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings. Sci Rep. 2018; 8(1):2082. PMC: 5794763. DOI: 10.1038/s41598-018-19628-z. View

Finetti C, Sola L, Pezzullo M, Prosperi D, Colombo M, Riva B . Click Chemistry Immobilization of Antibodies on Polymer Coated Gold Nanoparticles. Langmuir. 2016; 32(29):7435-41. DOI: 10.1021/acs.langmuir.6b01142. View

Aubin-Tam M, Hamad-Schifferli K . Structure and function of nanoparticle-protein conjugates. Biomed Mater. 2008; 3(3):034001. DOI: 10.1088/1748-6041/3/3/034001. View

Salunkhe A, Khot V, Patil S, Tofail S, Bauer J, Thorat N . MRI Guided Magneto-chemotherapy with High-Magnetic-Moment Iron Oxide Nanoparticles for Cancer Theranostics. ACS Appl Bio Mater. 2022; 3(4):2305-2313. DOI: 10.1021/acsabm.0c00077. View

Oztas D, Altunbek M, Uzunoglu D, Yilmaz H, Cetin D, Suludere Z . Tracing Size and Surface Chemistry-Dependent Endosomal Uptake of Gold Nanoparticles Using Surface-Enhanced Raman Scattering. Langmuir. 2019; 35(11):4020-4028. DOI: 10.1021/acs.langmuir.8b03988. View

10.

Rodal S, Skretting G, Garred O, Vilhardt F, van Deurs B, Sandvig K . Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999; 10(4):961-74. PMC: 25220. DOI: 10.1091/mbc.10.4.961. View

11.

Javed I, He J, Kakinen A, Faridi A, Yang W, Davis T . Probing the Aggregation and Immune Response of Human Islet Amyloid Polypeptides with Ligand-Stabilized Gold Nanoparticles. ACS Appl Mater Interfaces. 2019; 11(11):10462-10471. DOI: 10.1021/acsami.8b19506. View

12.

Khlebtsov N, Dykman L . Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. Chem Soc Rev. 2010; 40(3):1647-71. DOI: 10.1039/c0cs00018c. View

13.

Allard-Vannier E, Herve-Aubert K, Kaaki K, Blondy T, Shebanova A, Shaitan K . Folic acid-capped PEGylated magnetic nanoparticles enter cancer cells mostly via clathrin-dependent endocytosis. Biochim Biophys Acta Gen Subj. 2016; 1861(6):1578-1586. DOI: 10.1016/j.bbagen.2016.11.045. View

14.

Dreifuss T, Ben-Gal T, Shamalov K, Weiss A, Jacob A, Sadan T . Uptake mechanism of metabolic-targeted gold nanoparticles. Nanomedicine (Lond). 2018; 13(13):1535-1549. DOI: 10.2217/nnm-2018-0022. View

15.

Bobo D, Robinson K, Islam J, Thurecht K, Corrie S . Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date. Pharm Res. 2016; 33(10):2373-87. DOI: 10.1007/s11095-016-1958-5. View

16.

Gunnarsson S, Bernfur K, Englund-Johansson U, Johansson F, Cedervall T . Analysis of complexes formed by small gold nanoparticles in low concentration in cell culture media. PLoS One. 2019; 14(6):e0218211. PMC: 6568402. DOI: 10.1371/journal.pone.0218211. View

17.

Collins D, Bossenmaier B, Kollmorgen G, Niederfellner G . Acquired Resistance to Antibody-Drug Conjugates. Cancers (Basel). 2019; 11(3). PMC: 6468698. DOI: 10.3390/cancers11030394. View

18.

Sapsford K, Tyner K, Dair B, Deschamps J, Medintz I . Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques. Anal Chem. 2011; 83(12):4453-88. DOI: 10.1021/ac200853a. View

19.

Foroozandeh P, Abdul Aziz A . Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles. Nanoscale Res Lett. 2018; 13(1):339. PMC: 6202307. DOI: 10.1186/s11671-018-2728-6. View

20.

Bohmer N, Jordan A . Caveolin-1 and CDC42 mediated endocytosis of silica-coated iron oxide nanoparticles in HeLa cells. Beilstein J Nanotechnol. 2015; 6:167-76. PMC: 4311761. DOI: 10.3762/bjnano.6.16. View