Long Intergenic Noncoding RNA01134 Accelerates Hepatocellular Carcinoma Progression by Sponging MicroRNA-4784 and Downregulating Structure Specific Recognition Protein 1

Overview

Journal Bioengineered

Date 2020 Sep 24

PMID 32970959

Citations 21

Authors

ShiYang Zheng

Yan Guo

Lizhen Dai

Ziming Liang

Qing Yang

Shuhong Yi

Affiliations

Soon will be listed here.

Abstract

Dysregulation of long noncoding RNAs (lncRNAs) has been suggested to foster the carcinogenesis of hepatocellular carcinoma (HCC). To date, the role of long intergenic noncoding RNA01134 (LINC01134) in HCC have never been researched yet. Herein, we found that LINC01134 was highly expressed in HCC tissues in comparison with the matched normal liver tissues and increased LINC01134 expression correlated with shorter overall survival of patients with HCC. Additionally, we demonstrated LINC01134 downregulation significantly suppressed the proliferation ability and colony formation capacity of HCC cells. Furthermore, we revealed that LINC01134 functioned as a competitive endogenous RNA (ceRNA) for miR-4784 to upregulate structure-specific recognition protein 1 (SSRP1) in HCC cells. Meanwhile, miR-4784 inhibitor or restoration of SSRP1 could markedly attenuate the inhibitory effect of LINC01134 downregulation on HCC cells. Taken together, LINC01134 may promote the carcinogenesis of HCC at least partly via the miR-4784/SSRP1 axis. Therefore, LINC01134/miR-4784/SSRP1 axis should be developed as the promising therapeutic target for HCC.

Citing Articles

LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma.

Yu Y, Wang J, Guo Q, Luo H Front Oncol. 2024; 14:1265762.

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Lu J, Yang Y, Liu X, Chen X, Song W, Liu Z Cell Death Dis. 2023; 14(11):713.

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Comprehensive Analysis of LINC01615 in Head and Neck Squamous Cell Carcinoma: A Hub Biomarker Identified by Machine Learning and Experimental Validation.

Yin X, Wang J, Bian Y, Jia Q, Shen Z, Zhang H J Oncol. 2022; 2022:5039962.

PMID: 35794984 PMC: 9252709. DOI: 10.1155/2022/5039962.

Establishment of a lncRNA-Based Prognostic Gene Signature Associated With Altered Immune Responses in HCC.

Li X, Zhang Z, Liu M, Fu X, A J, Chen G Front Immunol. 2022; 13:880288.

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