Recent Advances on the Roles of LncRNAs in Cardiovascular Disease

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2020 Sep 24

PMID 32969576

Citations 34

Authors

Yexian Fang

Yuerong Xu

Runze Wang

Lang Hu

Dong Guo

Feng Xue

Wangang Guo

Dongwei Zhang

Jianqiang Hu

Yan Li

Wei Zhang

Mingming Zhang

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases are a main cause of mortality whose prevalence continues to increase worldwide. Long non-coding RNAs (lncRNAs) regulate a variety of biological processes by modifying and regulating transcription of coding genes, directly binding to proteins and even coding proteins themselves. LncRNAs play key roles in the occurrence and development of myocardial infarction, heart failure, myocardial hypertrophy, arrhythmias and other pathological processes that significantly affect the prognosis and survival of patients with cardiovascular diseases. We here review the latest research on lncRNAs in cardiovascular diseases as a basis to formulate future research on prevention and treatment of cardiovascular diseases.

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References

Rezaie J, Rahbarghazi R, Pezeshki M, Mazhar M, Yekani F, Khaksar M . Cardioprotective role of extracellular vesicles: A highlight on exosome beneficial effects in cardiovascular diseases. J Cell Physiol. 2019; 234(12):21732-21745. DOI: 10.1002/jcp.28894. View

Lorenzen J, Thum T . Long noncoding RNAs in kidney and cardiovascular diseases. Nat Rev Nephrol. 2016; 12(6):360-73. DOI: 10.1038/nrneph.2016.51. View

. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390(10100):1211-1259. PMC: 5605509. DOI: 10.1016/S0140-6736(17)32154-2. View

Ahmad F, Seidman J, Seidman C . The genetic basis for cardiac remodeling. Annu Rev Genomics Hum Genet. 2005; 6:185-216. DOI: 10.1146/annurev.genom.6.080604.162132. View

Vausort M, Wagner D, Devaux Y . Long noncoding RNAs in patients with acute myocardial infarction. Circ Res. 2014; 115(7):668-77. DOI: 10.1161/CIRCRESAHA.115.303836. View

Schmitz S, Grote P, Herrmann B . Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 2016; 73(13):2491-509. PMC: 4894931. DOI: 10.1007/s00018-016-2174-5. View

Li X, He X, Wang H, Li M, Huang S, Chen G . Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration. Cardiovasc Res. 2018; 114(12):1642-1655. PMC: 6148334. DOI: 10.1093/cvr/cvy075. View

Frade A, Laugier L, Ferreira L, Baron M, Benvenuti L, Teixeira P . Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease. J Infect Dis. 2016; 214(1):161-5. DOI: 10.1093/infdis/jiw095. View

Han P, Li W, Lin C, Yang J, Shang C, Nuernberg S . A long noncoding RNA protects the heart from pathological hypertrophy. Nature. 2014; 514(7520):102-106. PMC: 4184960. DOI: 10.1038/nature13596. View

10.

Wang K, Liu C, Zhou L, Wang J, Wang M, Zhao B . APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. Nat Commun. 2015; 6:6779. DOI: 10.1038/ncomms7779. View

11.

Zhang Y, Jiao L, Sun L, Li Y, Gao Y, Xu C . LncRNA as a SERCA2a Inhibitor to Cause Intracellular Ca Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction. Circ Res. 2018; 122(10):1354-1368. PMC: 5959220. DOI: 10.1161/CIRCRESAHA.117.312117. View

12.

Holdt L, Beutner F, Scholz M, Gielen S, Gabel G, Bergert H . ANRIL expression is associated with atherosclerosis risk at chromosome 9p21. Arterioscler Thromb Vasc Biol. 2010; 30(3):620-7. DOI: 10.1161/ATVBAHA.109.196832. View

13.

Zhu B, Zhang L, Liang C, Liu B, Pan X, Wang Y . Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-B/TNF- Signaling Pathway. Oxid Med Cell Longev. 2019; 2019:9739258. PMC: 6476062. DOI: 10.1155/2019/9739258. View

14.

Zhang Y, Du W, Yang B . Long non-coding RNAs as new regulators of cardiac electrophysiology and arrhythmias: Molecular mechanisms, therapeutic implications and challenges. Pharmacol Ther. 2019; 203:107389. DOI: 10.1016/j.pharmthera.2019.06.011. View

15.

Furio-Tari P, Tarazona S, Gabaldon T, Enright A, Conesa A . spongeScan: A web for detecting microRNA binding elements in lncRNA sequences. Nucleic Acids Res. 2016; 44(W1):W176-80. PMC: 4987953. DOI: 10.1093/nar/gkw443. View

16.

Omura J, Habbout K, Shimauchi T, Wu W, Breuils-Bonnet S, Tremblay E . Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension. Circulation. 2020; 142(15):1464-1484. DOI: 10.1161/CIRCULATIONAHA.120.047626. View

17.

Chen G, Li H, Li X, Li B, Zhong L, Huang S . Loss of long non-coding RNA CRRL promotes cardiomyocyte regeneration and improves cardiac repair by functioning as a competing endogenous RNA. J Mol Cell Cardiol. 2018; 122:152-164. DOI: 10.1016/j.yjmcc.2018.08.013. View

18.

Wang Z, Zhang X, Ji Y, Zhang P, Deng K, Gong J . The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016; 22(10):1131-1139. PMC: 5053883. DOI: 10.1038/nm.4179. View

19.

Piccoli M, Gupta S, Viereck J, Foinquinos A, Samolovac S, Kramer F . Inhibition of the Cardiac Fibroblast-Enriched lncRNA Prevents Cardiac Fibrosis and Diastolic Dysfunction. Circ Res. 2017; 121(5):575-583. DOI: 10.1161/CIRCRESAHA.117.310624. View

20.

Mummery C, Davis R, Krieger J . Challenges in using stem cells for cardiac repair. Sci Transl Med. 2010; 2(27):27ps17. DOI: 10.1126/scitranslmed.3000558. View