Nighttime Agitation and Restless Legs Syndrome in Persons With Alzheimer's Disease: Study Protocol for a Double-Blind, Placebo-Controlled, Randomized Trial (NightRest)

Overview

Journal Res Gerontol Nurs

Specialties Geriatrics
Nursing

Date 2020 Sep 23

PMID 32966585

Citations 2

Authors

Kathy Richards

Janet Morrison

Yan-Yan Wang

Angelica Rangel

Ana Loera

Alexandra Hanlon

Alicia Lozano

Christine Kovach

Nalaka Gooneratne

Liam Fry

Richard Allen

Affiliations

Soon will be listed here.

Abstract

Targets: Persons with AD with nighttime agitation potentially caused by RLS.

Intervention Description: Diagnose RLS and determine the effect of GEn.

Mechanisms Of Action: The frequency of RLS behaviors will mediate the relationship between GEn and nighttime agitation.

Outcomes: Determine the effect of GEn on nighttime agitation, sleep, and antipsychotic medications.

Trial Registration: ClinicalTrials.gov Identifier: NCT03082755 (Date of registration March 6, 2017). [Research in Gerontological Nursing, 13(6), 280-288.].

Citing Articles

Non-pharmacological interventions for sleep disturbances in people with dementia.

Wilfling D, Calo S, Dichter M, Meyer G, Mohler R, Kopke S Cochrane Database Syst Rev. 2023; 1:CD011881.

PMID: 36594432 PMC: 9808594. DOI: 10.1002/14651858.CD011881.pub2.

Nighttime Agitation in Persons with Dementia as a Manifestation of Restless Legs Syndrome.

Richards K, Allen R, Morrison J, Fry L, Kovach C, Rangel A J Am Med Dir Assoc. 2020; 22(7):1410-1414.

PMID: 33347845 PMC: 8211902. DOI: 10.1016/j.jamda.2020.11.026.

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