KLF5 Regulates Epithelial-mesenchymal Transition of Liver Cancer Cells in the Context of P53 Loss Through MiR-192 Targeting of ZEB2

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2020 Sep 23

PMID 32965165

Citations 7

Authors

Lan Sun

Xiaona Zhou

Yanmeng Li

Wei Chen

Shanna Wu

Bei Zhang

Jingyi Yao

Anjian Xu

Affiliations

Soon will be listed here.

Abstract

Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tumor antigen p53 (p53). Furthermore, zinc finger E-box-binding homeobox 2 (ZEB2) is the main regulator of KLF5 in EMT in liver cancer cells in the context of p53 loss. Most importantly, the regulation of ZEB2 by p53 and KLF5 is indirect and that miR-192 mediates this regulation. Finally, we find that in invasive liver cancer, KLF5 is absent in the context of p53 loss or mutation.

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