Recent Progress of Hypoxia-modulated Multifunctional Nanomedicines to Enhance Photodynamic Therapy: Opportunities, Challenges, and Future Development

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2020 Sep 23

PMID 32963938

Citations 65

Authors

Yixin Sun

Dongyang Zhao

Gang Wang

Yang Wang

Linlin Cao

Jin Sun

Qikun Jiang

Zhonggui He

Affiliations

Soon will be listed here.

Abstract

Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors. Moreover, PDT could further worsen hypoxia. Therefore, developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment. In this review, the mechanism and relationship of tumor hypoxia and PDT are discussed. Moreover, we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT, such as oxygen supply systems, down-regulation of oxygen consumption and hypoxia utilization. Finally, the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT.

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