Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis

Overview

Journal Life (Basel)

Specialty Biology

Date 2020 Sep 23

PMID 32961879

Citations 3

Authors

Milena Racis

Anna Stanislawska-Sachadyn

Wojciech Sobiczewski

Marcin Wirtwein

Michal Krzeminski

Natalia Krawczynska

Janusz Limon

Andrzej Rynkiewicz

Marcin Gruchala

Affiliations

Soon will be listed here.

Abstract

Oxidative stress is believed to play a critical role in atherosclerosis initiation and progression. In line with this, in a group of 1099 subjects, we determined eight single nucleotide polymorphisms (SNPs) related to oxidative stress ( c.575A>G, c.-463G>A, c.47T>C, c.-590C>T, c.894G>T, c.-786T>C, c.214C>T, and c.-932A>G) and assessed the extent of atherosclerosis in coronary arteries based on Gensini score. An increased risk of having a Gensini score in the higher half of the distribution was observed for the c.575G allele (odds ratio (OR) = 1.27, 95% confidence interval (CI): 1.004-1.617, = 0.046). Next, the genetic risk score (GRS) for the additive effect of the total number of pro-oxidative alleles was assessed. We noted an increase in the risk of having a Gensini score above the median with the maximum number of risk alleles (OR = 2.47, 95% CI: 1.19-5.23, = 0.014). A univariate Spearman's test revealed significant correlation between the total number of pro-oxidant alleles (GRS) and the Gensini score (ρ = 0.068, = 0.03). In conclusion, the c.575A>G variant and the high number of risk alleles (GRS) were independent risk factors for a high Gensini score. We suggest, however, that GRS might occur as a more valuable component in adding a predictive value to the genetic background of atherosclerosis.

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