ERADicating Stem Cells from Their Niche

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2020 Sep 22

PMID 32958855

Authors

Kentson Lam

Robert A J Signer

Affiliations

Soon will be listed here.

References

Hidalgo San Jose L, Signer R . Cell-type-specific quantification of protein synthesis in vivo. Nat Protoc. 2019; 14(2):441-460. PMC: 8105873. DOI: 10.1038/s41596-018-0100-z. View

Chapple R, Hu T, Tseng Y, Liu L, Kitano A, Luu V . ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response. Elife. 2018; 7. PMC: 5829925. DOI: 10.7554/eLife.31159. View

Mueller B, Lilley B, Ploegh H . SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol. 2006; 175(2):261-70. PMC: 2064567. DOI: 10.1083/jcb.200605196. View

Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y . Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat Cell Biol. 2020; 22(10):1162-1169. PMC: 7888538. DOI: 10.1038/s41556-020-00581-x. View

van Galen P, Kreso A, Mbong N, Kent D, Fitzmaurice T, Chambers J . The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature. 2014; 510(7504):268-72. DOI: 10.1038/nature13228. View

Liu L, Zhao M, Jin X, Ney G, Yang K, Peng F . Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells. Nat Cell Biol. 2019; 21(3):328-337. PMC: 6745703. DOI: 10.1038/s41556-019-0285-6. View

Liu L, Inoki A, Fan K, Mao F, Shi G, Jin X . ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity. Blood. 2020; 136(26):2975-2986. PMC: 7770563. DOI: 10.1182/blood.2020007975. View

Signer R, Magee J, Salic A, Morrison S . Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014; 509(7498):49-54. PMC: 4015626. DOI: 10.1038/nature13035. View

Crane G, Jeffery E, Morrison S . Adult haematopoietic stem cell niches. Nat Rev Immunol. 2017; 17(9):573-590. DOI: 10.1038/nri.2017.53. View

10.

Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y . Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell. 2008; 1(6):685-97. DOI: 10.1016/j.stem.2007.10.020. View

11.

van Galen P, Mbong N, Kreso A, Schoof E, Wagenblast E, Ng S . Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia. Cell Rep. 2018; 25(5):1109-1117.e5. DOI: 10.1016/j.celrep.2018.10.021. View

12.

Chua B, Signer R . Hematopoietic stem cell regulation by the proteostasis network. Curr Opin Hematol. 2020; 27(4):254-263. PMC: 7357843. DOI: 10.1097/MOH.0000000000000591. View

13.

Gekas C, Graf T . CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age. Blood. 2013; 121(22):4463-72. DOI: 10.1182/blood-2012-09-457929. View

14.

Methia N, Louache F, Vainchenker W, Wendling F . Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood. 1993; 82(5):1395-401. View

15.

Rabe J, Hernandez G, Chavez J, Mills T, Nerlov C, Pietras E . CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions. Exp Hematol. 2019; 81:1-15.e6. PMC: 6938677. DOI: 10.1016/j.exphem.2019.12.003. View

16.

Brodsky J . Cleaning up: ER-associated degradation to the rescue. Cell. 2012; 151(6):1163-7. PMC: 3521611. DOI: 10.1016/j.cell.2012.11.012. View