Genetic Variants and Haplotypes in Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study

Overview

Journal DNA Cell Biol

Publisher Mary Ann Liebert

Specialties Cell Biology
Molecular Biology

Date 2020 Sep 21

PMID 32955941

Citations 3

Authors

Nonanzit Perez-Hernandez

Rosalinda Posadas-Sanchez

Gilberto Vargas-Alarcon

Benny Giovanni Cazarin-Santos

Antonio Miranda-Duarte

Jose Manuel Rodriguez-Perez

Affiliations

Soon will be listed here.

Abstract

Basic and clinical research have demonstrated that osteoprotegerin (OPG) plays an important role in the development and progression of cardiovascular diseases. The aim of this study was to evaluate the association of four polymorphic sites (rs2073618, rs3134069, rs3134070, and rs3102735) of gene with premature coronary artery disease (pCAD), and with cardiometabolic parameters. The polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays with real-time PCR in 1098 individuals with pCAD and 1041 healthy controls. rs2073618 polymorphism was associated with a high risk of developing pCAD according to different inheritance models: additive ( = 0.001; odds ratio [OR] = 1.283), dominant ( = 0.006; OR = 1.383), recessive ( = 0.011; OR = 1.423), and codominant 2 ( = 0.001; OR = 1.646). The four polymorphisms were associated with different cardiovascular risk factors in individuals with pCAD and controls. Our results suggest that rs2073618 polymorphism is associated with an increased risk of pCAD. In addition, two haplotypes were associated with pCAD, one increasing the risk () and another one as protective ().

Citing Articles

rs1024611 Polymorphism, MCP-1 Concentrations, and Premature Coronary Artery Disease: Results of the Genetics of Atherosclerotic Disease (GEA) Mexican Study.

Posadas-Sanchez R, Velazquez-Sanchez F, Reyes-Barrera J, Cardoso-Saldana G, Velazquez-Argueta F, Antonio-Villa N Biomedicines. 2024; 12(6).

PMID: 38927499 PMC: 11201762. DOI: 10.3390/biomedicines12061292.

Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population.

Cazarin-Santos B, Perez-Hernandez N, Posadas-Sanchez R, Vargas-Alarcon G, Perez-Mendez O, Rodriguez-Silverio J Diagnostics (Basel). 2022; 12(6).

PMID: 35741244 PMC: 9221599. DOI: 10.3390/diagnostics12061433.

Osteoprotegerin and MTHFR gene variations in rheumatoid arthritis: association with disease susceptibility and markers of subclinical atherosclerosis.

Arida A, Nezos A, Papadaki I, Sfikakis P, Mavragani C Sci Rep. 2022; 12(1):9534.

PMID: 35680906 PMC: 9184606. DOI: 10.1038/s41598-022-13265-3.

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