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COVID-19-associated Sleep Disorders: A Case Report

Overview
Journal Neurobiol Sleep Circadian Rhythms
Date 2020 Sep 21
PMID 32954046
Citations 13
Authors
Abeer A Tony
Effat Ae Tony
Shazly B Ali
Azza M EzzEldin
Amal A Mahmoud
Affiliations
Soon will be listed here.
Abstract

Purpose: We reported one patient infected with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) presented with sleep disorders; insomnia and restless leg syndrome.

Methods: Patient data were obtained from medical records from Al-Raghy Isolation Hospital in Assuit University.

Results: A 49-year-old female patient presented with insomnia and restless leg syndrome associated with anosmia, ageusia. Three days before, she had developed a cough, malaise and athenia, headache, arthralgia, myalgia affecting mainly upper limbs, diarrhea and a fever followed by tachypnea. The naso-oropharyngeal swab test for coronavirus disease 2019 (COVID-19) by qualitative real-time reverse-transcriptase-polymerase-chain-reaction assay was positive. The patient was treated with Oseltamivir 75mg and clarithromycin 500 mg (12 hourly for each respectively) for 10 days with paracetamol. Two weeks later, the patient made a complete neurological and respiratory recovery.

Conclusion: Our case highlighted the rare occurrence of restless leg syndrome and insomnia during the COVID-19 pandemic. The era of sleep disorders spectrum in patients with COVID-19 remains to be characterized suggesting a frightening scientific association between COVID-19 and neuropsychiatric illness.

Citing Articles

Prevalence of restless legs syndrome during the 2019 coronavirus disease pandemic in South Korea: A nationwide cross-sectional population-based study.

Kim J, Kang K, Kim K, Cho Y Front Neurol. 2023; 13:1101711.

PMID: 36619937 PMC: 9814963. DOI: 10.3389/fneur.2022.1101711.

On Patterns of Neuropsychiatric Symptoms in Patients With COVID-19: A Systematic Review of Case Reports.

Idehen J, Kazi U, Quainoo-Acquah J, Sperry B, Zaman I, Goodarzi A Cureus. 2022; 14(5):e25004.

PMID: 35712343 PMC: 9194523. DOI: 10.7759/cureus.25004.

[Cognitive disorders and sleep disturbances in long COVID].

Schilling C, Meyer-Lindenberg A, Schweiger J Nervenarzt. 2022; 93(8):779-787.

PMID: 35576015 PMC: 9109661. DOI: 10.1007/s00115-022-01297-z.

The COVID-19 pandemic, an environmental neurology perspective.

Reis J, Buguet A, Roman G, Spencer P Rev Neurol (Paris). 2022; 178(6):499-511.

PMID: 35568518 PMC: 8938187. DOI: 10.1016/j.neurol.2022.02.455.

Restless legs syndrome is associated with long-COVID in women.

Weinstock L, Brook J, Walters A, Goris A, Afrin L, Molderings G J Clin Sleep Med. 2022; 18(5):1413-1418.

PMID: 35484639 PMC: 9059584. DOI: 10.5664/jcsm.9898.

References
1.
Bettis R, Iacuzio D, Jung T, Fuchs R, Aultman R, Gyldmark M . Impact of influenza treatment with oseltamivir on health, sleep and daily activities of otherwise healthy adults and adolescents. Clin Drug Investig. 2006; 26(6):329-40. DOI: 10.2165/00044011-200626060-00004. View
2.
Chockalingam A, Hamed S, Goodwin D, Rosenzweig B, Pang E, Boyne 2nd M . The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model. Dis Markers. 2016; 2016:9296457. PMC: 4824134. DOI: 10.1155/2016/9296457. View
3.
Weinstock L, Walters A, Paueksakon P . Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. Sleep Med Rev. 2012; 16(4):341-54. DOI: 10.1016/j.smrv.2011.09.003. View
4.
Gutierrez-Ortiz C, Mendez-Guerrero A, Rodrigo-Rey S, San Pedro-Murillo E, Bermejo-Guerrero L, Gordo-Manas R . Miller Fisher syndrome and polyneuritis cranialis in COVID-19. Neurology. 2020; 95(5):e601-e605. DOI: 10.1212/WNL.0000000000009619. View
5.
Asif N, Iqbal R, Nazir C . Human immune system during sleep. Am J Clin Exp Immunol. 2018; 6(6):92-96. PMC: 5768894. View