Role of Inflammatory Indices in Management of Hepatocellular Carcinoma-neutrophil to Lymphocyte Ratio

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2020 Sep 21

PMID 32953712

Citations 21

Authors

Vishal G Shelat

Affiliations

Soon will be listed here.

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References

Li S, Feng X, Cao G, Wang Q, Wang L . Prognostic significance of inflammatory indices in hepatocellular carcinoma treated with transarterial chemoembolization: A systematic review and meta-analysis. PLoS One. 2020; 15(3):e0230879. PMC: 7098645. DOI: 10.1371/journal.pone.0230879. View

Liu C, Li L, Lu W, Du H, Yan L, Yang J . Neutrophil-lymphocyte Ratio Plus Prognostic Nutritional Index Predicts the Outcomes of Patients with Unresectable Hepatocellular Carcinoma After Transarterial Chemoembolization. Sci Rep. 2017; 7(1):13873. PMC: 5654965. DOI: 10.1038/s41598-017-13239-w. View

Fogar P, Sperti C, Basso D, Sanzari M, Greco E, Davoli C . Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas. 2005; 32(1):22-8. DOI: 10.1097/01.mpa.0000188305.90290.50. View

Odabasi M, Yesil A, Ozkara S, Paker N, Ozkan S, Eris C . Role of human neutrophil gelatinase associated lipocalin (NGAL) and Matrix Metalloproteinase-9 (MMP-9) overexpression in neoplastic colon polyps. Int J Clin Exp Med. 2014; 7(9):2804-11. PMC: 4211792. View

Kusumanto Y, Dam W, Hospers G, Meijer C, Mulder N . Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis. 2004; 6(4):283-7. DOI: 10.1023/B:AGEN.0000029415.62384.ba. View

Kabir T, Ye M, Mohd Noor N, Woon W, Junnarkar S, Shelat V . Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma. Int J Hepatol. 2019; 2019:4239463. PMC: 6466930. DOI: 10.1155/2019/4239463. View

Wang Y, Peng C, Cheng Z, Wang X, Wu L, Li J . The prognostic significance of preoperative neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma receiving hepatectomy: A systematic review and meta-analysis. Int J Surg. 2018; 55:73-80. DOI: 10.1016/j.ijsu.2018.05.022. View

Wang C, Wang M, Zhang X, Zhao S, Hu J, Han G . The neutrophil-to-lymphocyte ratio is a predictive factor for the survival of patients with hepatocellular carcinoma undergoing transarterial chemoembolization. Ann Transl Med. 2020; 8(8):541. PMC: 7214899. DOI: 10.21037/atm.2020.02.113. View

Sun X, Shi X, Chen Y, Wang C, Ma Q, Lv G . Elevated Preoperative Neutrophil-Lymphocyte Ratio Is Associated with Poor Prognosis in Hepatocellular Carcinoma Patients Treated with Liver Transplantation: A Meta-Analysis. Gastroenterol Res Pract. 2016; 2016:4743808. PMC: 4710922. DOI: 10.1155/2016/4743808. View

10.

Kobayashi N, Hiraoka N, Yamagami W, Ojima H, Kanai Y, Kosuge T . FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res. 2007; 13(3):902-11. DOI: 10.1158/1078-0432.CCR-06-2363. View

11.

Wu Y, Zhao Q, Peng C, Sun L, Li X, Kuang D . Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. J Pathol. 2011; 225(3):438-47. DOI: 10.1002/path.2947. View

12.

Jung M, Park Y, Jeong O, Seon J, Ryu S, Kim D . Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol. 2011; 104(5):504-10. DOI: 10.1002/jso.21986. View

13.

He C, Lin X . Inflammation scores predict the survival of patients with hepatocellular carcinoma who were treated with transarterial chemoembolization and recombinant human type-5 adenovirus H101. PLoS One. 2017; 12(3):e0174769. PMC: 5371390. DOI: 10.1371/journal.pone.0174769. View

14.

Zheng Y, Zhao W, Liu B, Lu L, He X, Huang J . The blood neutrophil-to-lymphocyte ratio predicts survival in patients with advanced hepatocellular carcinoma receiving sorafenib. Asian Pac J Cancer Prev. 2013; 14(9):5527-31. DOI: 10.7314/apjcp.2013.14.9.5527. View

15.

Zahorec R . Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001; 102(1):5-14. View

16.

Ahmed S, de Souza N, Qiao W, Kasai M, Jee Keem L, Shelat V . Quality of Life in Hepatocellular Carcinoma Patients Treated with Transarterial Chemoembolization. HPB Surg. 2016; 2016:6120143. PMC: 4838811. DOI: 10.1155/2016/6120143. View

17.

Huang Z, Luo J, Chen M, Li J, Shi M . Blood neutrophil-to-lymphocyte ratio predicts survival in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization. J Vasc Interv Radiol. 2011; 22(5):702-9. DOI: 10.1016/j.jvir.2010.12.041. View

18.

Gui C, Baey S, DCruz R, Shelat V . Trans-arterial chemoembolization + radiofrequency ablation versus surgical resection in hepatocellular carcinoma - A meta-analysis. Eur J Surg Oncol. 2020; 46(5):763-771. DOI: 10.1016/j.ejso.2020.01.004. View

19.

Li Y, Qiu S, Fan J, Zhou J, Gao Q, Xiao Y . Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection. J Hepatol. 2010; 54(3):497-505. DOI: 10.1016/j.jhep.2010.07.044. View

20.

Brodsky S, Mendelev N, Melamed M, Ramaswamy G . Vascular density and VEGF expression in hepatic lesions. J Gastrointestin Liver Dis. 2008; 16(4):373-7. View