Interaction of Nutrition and Infection: Macrophage Activity in Vitamin B12-deficient Rats Infected with Trypanosoma Lewisi

Overview

Journal J Natl Med Assoc

Publisher Elsevier

Specialty General Medicine

Date 1987 Apr 1

PMID 3295263

Citations 1

Authors

K G Thomaskutty

C M Lee

Affiliations

Soon will be listed here.

Abstract

MACROPHAGE ACTIVITY WAS STUDIED IN RATS INFECTED WITH TRYPANOSOMA LEWISI IN THREE PROTOCOL GROUPS: one group was fed complete diet, a second group was given a vitamin B(12)-deficient diet, and a third group was fed a pair-fed control (calorically restricted) diet. Throughout the observational period, in animals fed complete and pairfed diets, marked increases in acid phosphatase levels in peritoneal macrophages were directly related to the degree of parasitemia. Acid phosphatase levels in rats deprived of vitamin B(12) were approximately one third that of animals with an adequate supply of the vitamin. Irrespective of the diets, the infection with T lewisi also elicited increased macrophage phagocytosis of polystyrene latex particles and macrophage spreading. Both of these activities occurred at a much slower rate in the vitamin B(12)-deficient animals.

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References

Christie G, Bomford R . Mechanisms of macrophage activation by Corynebacterium parvum. I. In vitro experiments. Cell Immunol. 1975; 17(1):141-9. DOI: 10.1016/s0008-8749(75)80014-1. View

. Specificity of the macrophage spreading test with reference to Leishmania antigens and correlation with delayed hypersensitivity. Clin Exp Immunol. 1979; 36(1):38-45. PMC: 1537692. View

NORTH R, Mackaness G . ELECTRON MICROSCOPICAL OBSERVATIONS ON THE PERITONEAL MACROPHAGES OF NORMAL MICE AND MICE IMMUNISED WITH LISTERIA MONOCYTOGENES. II. STRUCTURE OF MACROPHAGES FROM IMMUNE MICE AND EARLY CYTOPLASMIC RESPONSE TO THE PRESENCE OF INGESTED BACTERIA. Br J Exp Pathol. 1963; 44:608-11. PMC: 2095210. View

Clinton B, Ortiz-Ortiz L, Garcia W, Martinez T, Capin R . Trypanosoma cruzi: early immune responses in infected mice. Exp Parasitol. 1975; 37(3):417-25. DOI: 10.1016/0014-4894(75)90012-0. View

AXLINE S . Isozymes of acid phosphatase in normal and Calmette-Guérin bacillus-induced rabbit alveolar macrophages. J Exp Med. 1968; 128(5):1031-48. PMC: 2138558. DOI: 10.1084/jem.128.5.1031. View

Johnson B, NEUMANN A . Crystalline vitamin B12 compared to antipernicious anemia liver extract for pig growth. J Biol Chem. 1949; 178(2):1001. View

COHN Z, Benson B . THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY. J Exp Med. 1965; 121:153-70. PMC: 2137972. DOI: 10.1084/jem.121.1.153. View

Ganguly R, Durieux M, Waldman R . Macrophage function in vitamin C-deficient guinea pigs. Am J Clin Nutr. 1976; 29(7):762-5. DOI: 10.1093/ajcn/29.7.762. View

Newberne P, Hunt C, Young V . The role of diet and the reticuloendothelial system in the response of rats to Salmonella typhilmurium infection. Br J Exp Pathol. 1968; 49(5):448-57. PMC: 2093893. View

10.

AXELROD A . Role of the B vitamins in the immune response. Adv Exp Med Biol. 1981; 135:93-106. DOI: 10.1007/978-1-4615-9200-6_5. View

11.

WEHINGER H, Hofacker M . Latex phagocytosis by polymorphonuclear leukocytes. In vitro and in vivo studies with a simple screening test. Eur J Pediatr. 1976; 123(2):125-32. DOI: 10.1007/BF00442642. View

12.

Giannella R, Broitman S, ZAMCHECK N . Competition between bacteria and intrinsic factor for vitamin B 12 : implications for vitamin B 12 malabsorption in intestinal bacterial overgrowth. Gastroenterology. 1972; 62(2):255-60. View

13.

COHN Z . Activation of mononuclear phagocytes: fact, fancy, and future. J Immunol. 1978; 121(3):813-6. View

14.

Thomaskutty K, Lee C . Interaction of nutrition and infection: effect of vitamin B12 deficiency on resistance to Trypanosoma lewisi. J Natl Med Assoc. 1985; 77(4):289-99. PMC: 2561845. View

15.

Bulmer G, Tacker J . Phagocytosis of Cryptococcus neoformans by alveolar macrophages. Infect Immun. 1975; 11(1):73-9. PMC: 415027. DOI: 10.1128/iai.11.1.73-79.1975. View

16.

Lewis U, REGISTER U . Distribution of vitamin B12 in natural materials. Proc Soc Exp Biol Med. 1949; 72(2):479-82. DOI: 10.3181/00379727-72-17475. View

17.

Nauss K, Newberne P . Effects of dietary folate, vitamin B12 and methionine/choline deficiency on immune function. Adv Exp Med Biol. 1981; 135:63-91. DOI: 10.1007/978-1-4615-9200-6_4. View

18.

Kaplan S, Basford R . Effect of vitamin B12 and folic acid deficiencies on neutrophil function. Blood. 1976; 47(5):801-5. View

19.

EMERSON G . Growth promoting activity of vitamin B12 in rats receiving thyroid substance. Proc Soc Exp Biol Med. 1949; 70(3):392-4. DOI: 10.3181/00379727-70-16937. View

20.

Schjonsby H, HOFSTAD T . The uptake of vitamin B12 by the sediment of jejunal contents in patients with the blind-loop syndrome. Scand J Gastroenterol. 1975; 10(3):305-9. View