Post-exposure Environment Modulates Long-term Developmental Ethanol Effects on Behavior, Neuroanatomy, and Cortical Oscillations

Overview

Journal Brain Res

Specialty Neurology

Date 2020 Sep 20

PMID 32950485

Citations 4

Authors

Justin Apuzzo

Mariko Saito

Donald A Wilson

Affiliations

Soon will be listed here.

Abstract

Developmental exposure to ethanol has a wide range of anatomical, cellular, physiological and behavioral impacts that can last throughout life. In humans, this cluster of effects is termed fetal alcohol spectrum disorder and is highly prevalent in western cultures. The ultimate expression of the effects of developmental ethanol exposure however can be influenced by post-exposure experience. Here we examined the effects of developmental binge exposure to ethanol (postnatal day 7) in C57BL/6By mice on a specific cohort of inter-related long-term outcomes including contextual memory, hippocampal parvalbumin-expressing neuron density, frontal cortex oscillations related to sleep-wake cycling including delta oscillation amplitude and sleep spindle density, and home-cage behavioral activity. When assessed in adults that were raised in standard housing, all of these factors were altered by early ethanol exposure compared to saline controls except home-cage activity. However, exposure to an enriched environment and exercise from weaning to postnatal day 90 reversed most of these ethanol-induced impairments including memory, CA1 but not dentate gyrus PV+ cell density, delta oscillations and sleep spindles, and enhanced home-cage behavioral activity in Saline- but not EtOH-treated mice. The results are discussed in terms of the inter-dependence of diverse developmental ethanol outcomes and potential mechanisms of post-exposure experiences to regulate those outcomes.

Citing Articles

Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development.

Wilson D, Sullivan R, Smiley J, Saito M, Raineki C Neurosci Biobehav Rev. 2024; 158:105567.

PMID: 38309498 PMC: 10923002. DOI: 10.1016/j.neubiorev.2024.105567.

Homeostatic NREM sleep and salience network function in adult mice exposed to ethanol during development.

Shah P, Kaneria A, Fleming G, Williams C, Sullivan R, Lemon C Front Neurosci. 2023; 17:1267542.

PMID: 38033546 PMC: 10682725. DOI: 10.3389/fnins.2023.1267542.

Effects of retinoic acid receptor α modulators on developmental ethanol-induced neurodegeneration and neuroinflammation.

Saito M, Subbanna S, Zhang X, Canals-Baker S, Smiley J, Wilson D Front Neurosci. 2023; 17:1170259.

PMID: 37205047 PMC: 10187544. DOI: 10.3389/fnins.2023.1170259.

Somatostatin neuron contributions to cortical slow wave dysfunction in adult mice exposed to developmental ethanol.

Wilson D, Fleming G, Williams C, Teixeira C, Smiley J, Saito M Front Neurosci. 2023; 17:1127711.

PMID: 37021136 PMC: 10067632. DOI: 10.3389/fnins.2023.1127711.

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