Hyperhomocysteinemia and Endothelial Dysfunction in Multiple Sclerosis

Overview

Journal Brain Sci

Publisher MDPI

Date 2020 Sep 19

PMID 32947812

Citations 7

Authors

Ekaterina Dubchenko

Alexander Ivanov

Natalia Spirina

Nina Smirnova

Mikhail Melnikov

Alexey Boyko

Evgeniy Gusev

Aslan Kubatiev

Affiliations

Soon will be listed here.

Abstract

Endothelial dysfunction is recognized as one of the leading factors in the pathogenesis of diseases of the central nervous system of various etiologies. Numerous studies have shown the role of hyperhomocysteinemia in the development of endothelial dysfunction and the prothrombogenic state. The most important condition in the development of multiple sclerosis (MS) is a dysregulation of the blood-brain barrier (BBB) and transendothelial leukocyte migration. It has been proven that homocysteine also contributes to the damage of neurons by the mechanism of excitotoxicity and the induction of the apoptosis of neurons. These processes can be one of the factors of neurodegenerative brain damage, which plays a leading role in the progression of MS. This review describes the pleiotropic effect of homocysteine on these processes and its role in MS pathogenesis.

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