SOX6: a Double-edged Sword for Ewing Sarcoma

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2020 Sep 18

PMID 32944640

Citations 4

Authors

Aruna Marchetto

Thomas G P Grunewald

Affiliations

Soon will be listed here.

Abstract

Developmental pathways play an important role in cancer. We have recently demonstrated that the constitutive activation of the developmental transcription factor SOX6 via the fusion oncoproteinne EWSR1-FLI1 (Ewing sarcoma breakpoint region 1 - Friend leukemia virus integration 1) contributes to the aggressive phenotype of Ewing sarcoma but on another hand provides an opportunity for targeted therapy.

Citing Articles

Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells.

Haight J, Koppenhafer S, Geary E, Gordon D Front Oncol. 2024; 14:1394653.

PMID: 38933441 PMC: 11199525. DOI: 10.3389/fonc.2024.1394653.

Clinical implications and genetical insights of SOX6 expression in acute myeloid leukemia.

Li Y, Jiang D, Zhang Q, Liu E, Shao H J Cancer Res Clin Oncol. 2022; 149(8):4443-4453.

PMID: 36117190 DOI: 10.1007/s00432-022-04349-8.

Identification of a novel circ_0001946/miR-1290/SOX6 ceRNA network in esophageal squamous cell cancer.

Wang J, Yao W, Li J, Zhang Q, Wei L Thorac Cancer. 2022; 13(9):1299-1310.

PMID: 35411716 PMC: 9058308. DOI: 10.1111/1759-7714.14381.

Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis.

Agalakova N, Kolodkin N, Adair C, Trashkov A, Bagrov A Int J Mol Sci. 2021; 22(4).

PMID: 33669287 PMC: 7920043. DOI: 10.3390/ijms22041941.

References

Musa J, Cidre-Aranaz F, Aynaud M, Orth M, Knott M, Mirabeau O . Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun. 2019; 10(1):4128. PMC: 6739408. DOI: 10.1038/s41467-019-12071-2. View

Grunewald T, Bernard V, Gilardi-Hebenstreit P, Raynal V, Surdez D, Aynaud M . Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. Nat Genet. 2015; 47(9):1073-8. PMC: 4591073. DOI: 10.1038/ng.3363. View

Zhou J, Chng W . Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion. 2012; 13(3):163-9. DOI: 10.1016/j.mito.2012.06.004. View

Monument M, Johnson K, McIlvaine E, Abegglen L, Watkins W, Jorde L . Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group. PLoS One. 2014; 9(8):e104378. PMC: 4122435. DOI: 10.1371/journal.pone.0104378. View

Grunewald T, Cidre-Aranaz F, Surdez D, Tomazou E, de Alava E, Kovar H . Ewing sarcoma. Nat Rev Dis Primers. 2018; 4(1):5. DOI: 10.1038/s41572-018-0003-x. View