Sja-miR-71a in Egg-derived Extracellular Vesicles Suppresses Liver Fibrosis Caused by Schistosomiasis Via Targeting Semaphorin 4D

Overview

Journal J Extracell Vesicles

Publisher Wiley

Date 2020 Sep 18

PMID 32944173

Citations 32

Authors

Lifu Wang

Yao Liao

Ruibing Yang

Zilong Yu

Lichao Zhang

Zifeng Zhu

Xiaoying Wu

Jia Shen

Jiahua Liu

Lian Xu

Zhongdao Wu

Xi Sun

Affiliations

Soon will be listed here.

Abstract

Schistosomiasis is characterized by liver fibrosis, and studies have indicated that () eggs can limit the progression of liver fibrosis. However, the detailed molecular mechanisms are yet unclear. Extracellular vesicles (EVs) contain a selection of miRNAs for long-distance exchange of information and act as an important pathway for host-parasite communication. This study aimed to explore the potential role of egg-derived EVs and its key miRNA in liver fibrosis. Herein, we found that egg-derived EVs can inhibit the activation of hepatic stellate cells, which is mediated via the high expression of Sja-miR-71a. Sja-miR-71a in EVs attenuates the pathological progression and liver fibrosis in infection. Sja-miR-71a inhibiting TGF-β1/SMAD and interleukin (IL)-13/STAT6 pathways via directly targeting semaphorin 4D (Sema4D). In addition, Sja-miR-71a can also suppress liver fibrosis by regulating Th1/Th2/Th17 and Treg balance. This study contributes to further understanding of the molecular mechanisms underlying -host interactions, and Sema4D may be a potential target for schistosomiasis liver fibrosis treatment.

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