Hypothetical Interpretation of the Calcium Paradox in Renin Secretion

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1988 Jun 1

PMID 3293796

Citations 6

Authors

R TAUGNER

R Nobiling

R Metz

F Taugner

C Buhrle

E HACKENTHAL

Affiliations

Soon will be listed here.

Abstract

Most renin-positive cells of the preglomerular arteriole are intermediate in morphological appearence between smooth muscle cells and epithelioid cells. Intermediate cells contain, in addition to secretory granules, contractile proteins arranged as a sublemmal network. The paradoxical (inhibitory) role of calcium in renin secretion is explained, on the basis of these findings, by an increased tone of the sublemmal network; this might impair the preexocytotic access of renin granules to the cell membrane.

Citing Articles

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Lack of connexin 40 decreases the calcium sensitivity of renin-secreting juxtaglomerular cells.

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Extracellular calcium exerts a dual effect on renin secretion from isolated mouse juxtaglomerular cells.

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Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney.

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