Recent Advances in Understanding Primary Ovarian Insufficiency

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2020 Sep 16

PMID 32934798

Citations 34

Authors

Victoria Wesevich

Amanada N Kellen

Lubna Pal

Affiliations

Soon will be listed here.

Abstract

Primary ovarian insufficiency (POI) is an uncommon yet devastating occurrence that results from a premature depletion of the ovarian pool of primordial follicles. Our understanding of both putative and plausible mechanisms underlying POI, previously considered to be largely "idiopathic", has been furthered over the past several years, largely due to advances in the field of genetics and through expansion of translational models for experimental research. In this review, our goal is to familiarize the multidisciplinary readers of the F1000 platform with the strides made in the field of reproductive medicine that hold both preventative and therapeutic implications for those women who are at risk for or who have POI.

Citing Articles

Human placental mesenchymal stem cells ameliorates premature ovarian insufficiency via modulating gut microbiota and suppressing the inflammation in rats.

Liu S, Wang T, Liu Y, Li Y, Ma J, Hu Q PLoS One. 2025; 20(3):e0313763.

PMID: 40043087 PMC: 11882084. DOI: 10.1371/journal.pone.0313763.

The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency.

Gao H, Cao X, Hua H, Zhu H Mol Genet Genomic Med. 2025; 13(2):e70074.

PMID: 39959946 PMC: 11831191. DOI: 10.1002/mgg3.70074.

Human hair follicle-derived mesenchymal stem cells improve ovarian function in cyclophosphamide-induced POF mice.

Mo J, Hu H, Li P, Ye Y, Chen W, Chen L Stem Cell Res Ther. 2025; 16(1):67.

PMID: 39934888 PMC: 11816600. DOI: 10.1186/s13287-024-04097-1.

The Role of Nutrient Supplements in Female Infertility: An Umbrella Review and Hierarchical Evidence Synthesis.

Pandey C, Maunder A, Liu J, Vaddiparthi V, Costello M, Bahri-Khomami M Nutrients. 2025; 17(1.

PMID: 39796491 PMC: 11722770. DOI: 10.3390/nu17010057.

Mesenchymal stem cell-derived extracellular vesicles therapy for primary ovarian insufficiency: a systematic review and meta-analysis of pre-clinical studies.

Rajai Firouzabadi S, Mohammadi I, Ghafourian K, Mofidi S, Firouzabadi S, Hashemi S J Ovarian Res. 2024; 17(1):200.

PMID: 39402602 PMC: 11472498. DOI: 10.1186/s13048-024-01513-1.

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