Effects of Maternal and Paternal Exercise on Offspring Metabolism

Overview

Journal Nat Metab

Publisher Springer Nature

Specialty Endocrinology

Date 2020 Sep 15

PMID 32929233

Citations 49

Authors

Joji Kusuyama

Ana Barbara Alves-Wagner

Nathan S Makarewicz

Laurie J Goodyear

Affiliations

Soon will be listed here.

Abstract

Maternal and paternal obesity and type 2 diabetes are recognized risk factors for the development of metabolic dysfunction in offspring, even when the offspring follow a healthful lifestyle. Multiple studies have demonstrated that regular physical activity in mothers and fathers has striking beneficial effects on offspring health, including preventing the development of metabolic disease in rodent offspring as they age. Here, we review the benefits of maternal and paternal exercise in combating the development of metabolic dysfunction in adult offspring, focusing on offspring glucose homeostasis and adaptations to metabolic tissues. We discuss recent findings regarding the roles of the placenta and sperm in mediating the effects of parental exercise on offspring metabolic health, as well as the mechanisms hypothesized to underlie these beneficial changes. Given the worldwide epidemics of obesity and type 2 diabetes, if these findings translate to humans, regular exercise during the reproductive years might limit the vicious cycles in which increased metabolic risk propagates across generations.

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