BK Polyomavirus Infection Promotes Growth and Aggressiveness in Bladder Cancer

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2020 Sep 15

PMID 32928222

Citations 9

Authors

Yigang Zeng

Jiajia Sun

Juan Bao

Tongyu Zhu

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies have confirmed the integration of the BK polyomavirus (BKPyV) gene into the cellular genome of urothelial carcinomas in transplant recipients, further confirming the correlation between BKPyV and urothelial carcinomas after transplantation. However, the role BKPyV infections play in the biological function of bladder cancer remains unclear.

Methods: We developed a BKPyV-infected bladder cancer cell model and a mice tumor model to discuss the role of BKPyV infections.

Results: Our research proves that BKPyV infections promote the proliferation, invasion and migration of bladder cancer cells, while the activation of β-catenin signaling pathway is one of its mediation mechanisms.

Conclusions: We first described BKPyV infection promotes the proliferation, invasion and migration of bladder cancer. We verified the role of β-catenin signaling pathway and Epithelial-Mesenchymal Transition effect in BKPyV-infected bladder cancer. These results provide meaningful information towards the diagnosis and treatment of clinical bladder cancer.

Citing Articles

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Dual roles of BK Polyomavirus in promoting urothelial carcinoma progression via regulating CLDN1.

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BK and JC polyomaviruses and risk of urothelial bladder carcinoma: a preliminary study in the northern shores of Persian Gulf, Iran.

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Moens U, Prezioso C, Pietropaolo V Front Microbiol. 2022; 13:834368.

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