ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer

Overview

Journal Nutrients

Date 2020 Sep 15

PMID 32927614

Citations 90

Authors

Stefania DAngelo

Maria Letizia Motti

Rosaria Meccariello

Affiliations

Soon will be listed here.

Abstract

Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the ω-6PUFAs. Both ω-3 and ω-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food-related disorders. In this review, we present ω-3 and ω-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of ω-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.

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References

Collett E, Davidson L, Fan Y, Lupton J, Chapkin R . n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. Am J Physiol Cell Physiol. 2001; 280(5):C1066-75. DOI: 10.1152/ajpcell.2001.280.5.C1066. View

Simopoulos A . An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients. 2016; 8(3):128. PMC: 4808858. DOI: 10.3390/nu8030128. View

Hotamisligil G . Inflammation and metabolic disorders. Nature. 2006; 444(7121):860-7. DOI: 10.1038/nature05485. View

Simopoulos A . Nutrigenetics/Nutrigenomics. Annu Rev Public Health. 2010; 31:53-68. DOI: 10.1146/annurev.publhealth.031809.130844. View

Colace L, Boccia S, De Maria R, Zeuner A . Colorectal cancer: towards new challenges and concepts of preventive healthcare. Ecancermedicalscience. 2017; 11:ed74. PMC: 5718247. DOI: 10.3332/ecancer.2017.ed74. View

Roh E, Song D, Kim M . Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. Exp Mol Med. 2016; 48:e216. PMC: 4892882. DOI: 10.1038/emm.2016.4. View

Burdge G, Jones A, Wootton S . Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*. Br J Nutr. 2002; 88(4):355-63. DOI: 10.1079/BJN2002662. View

Calder P . Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017; 45(5):1105-1115. DOI: 10.1042/BST20160474. View

Torres-Fuentes C, Schellekens H, Dinan T, Cryan J . A natural solution for obesity: bioactives for the prevention and treatment of weight gain. A review. Nutr Neurosci. 2014; 18(2):49-65. DOI: 10.1179/1476830513Y.0000000099. View

10.

Tsoukas M, Ko B, Witte T, Dincer F, Hardman W, Mantzoros C . Dietary walnut suppression of colorectal cancer in mice: Mediation by miRNA patterns and fatty acid incorporation. J Nutr Biochem. 2015; 26(7):776-83. DOI: 10.1016/j.jnutbio.2015.02.009. View

11.

Meccariello R . Endocannabinoid System in Health and Disease: Current Situation and Future Perspectives. Int J Mol Sci. 2020; 21(10). PMC: 7278997. DOI: 10.3390/ijms21103549. View

12.

Nording M, Yang J, Georgi K, Hegedus Karbowski C, German J, Weiss R . Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PLoS One. 2013; 8(10):e76575. PMC: 3811983. DOI: 10.1371/journal.pone.0076575. View

13.

DiNicolantonio J, OKeefe J . Importance of maintaining a low omega-6/omega-3 ratio for reducing inflammation. Open Heart. 2018; 5(2):e000946. PMC: 6269634. DOI: 10.1136/openhrt-2018-000946. View

14.

Schley P, Brindley D, Field C . (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells. J Nutr. 2007; 137(3):548-53. DOI: 10.1093/jn/137.3.548. View

15.

Harris W, Mozaffarian D, Rimm E, Kris-Etherton P, Rudel L, Appel L . Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on.... Circulation. 2009; 119(6):902-7. DOI: 10.1161/CIRCULATIONAHA.108.191627. View

16.

Wortman P, Miyazaki Y, Kalupahana N, Kim S, Hansen-Petrik M, Saxton A . n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes. Nutr Metab (Lond). 2009; 6:5. PMC: 2646735. DOI: 10.1186/1743-7075-6-5. View

17.

Weylandt K, Serini S, Chen Y, Su H, Lim K, Cittadini A . Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence. Biomed Res Int. 2015; 2015:143109. PMC: 4537707. DOI: 10.1155/2015/143109. View

18.

Kalupahana N, Claycombe K, Moustaid-Moussa N . (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Adv Nutr. 2012; 2(4):304-16. PMC: 3125680. DOI: 10.3945/an.111.000505. View

19.

Sebio A, Kahn M, Lenz H . The potential of targeting Wnt/β-catenin in colon cancer. Expert Opin Ther Targets. 2014; 18(6):611-5. DOI: 10.1517/14728222.2014.906580. View

20.

Sam A, Salem V, Ghatei M . Rimonabant: From RIO to Ban. J Obes. 2011; 2011:432607. PMC: 3136184. DOI: 10.1155/2011/432607. View