The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2020 Sep 14

PMID 32922208

Citations 22

Authors

Xueyi Zhu

Jie Cui

La Yi

Jingjing Qin

Wuniqiemu Tulake

Fangzhou Teng

Weifeng Tang

Ying Wei

Jingcheng Dong

Affiliations

Soon will be listed here.

Abstract

Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.

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