Identifying the Association Between Single Nucleotide Polymorphisms in , , and and Type 2 Diabetes Mellitus in a Chinese Population

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2020 Sep 14

PMID 32922204

Citations 5

Authors

Yiping Li

Keyu Shen

Chuanyin Li

Ying Yang

Man Yang

Wenyu Tao

Siqi He

Li Shi

YuFeng Yao

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes mellitus (T2DM) has a high global prevalence, and insufficient insulin secretion is one of the major reasons for its development. Therefore, investigating the association between T2DM and the single nucleotide polymorphisms (SNPs) in genes associated with insulin secretion is necessary. T2DM (1,194) and nondiabetic (NDM) (1,292) subjects were enrolled and the ten single nucleotide polymorphisms (SNPs) in , , and associated with insulin secretion were genotyped in a Chinese population. Our data revealed that the rs2237897T allele in is the protective allele for T2DM (0.001, OR=0.793; 95%CI: 0.705-0.893). However, the A allele of rs1552224 in may be a risk factor for T2DM (0.002, OR=12.070; 95% CI: 1.578-92.337). The haplotype analysis revealed that rs151290-rs2237892CC and rs2237895-rs2237897CC in constitute the risk haplotype in T2DM development (0.010, OR=1.160; 95% CI: 1.037-1.299 and 0.004, OR=1.192; 95% CI: 1.057-1.344). Moreover, rs2237895-rs2237897AT in constitutes the protective haplotype in T2DM (0.001, OR=0.819; 95% CI: 0.727-0.923). In the inheritance models analysis, the rs2283228 (C/A-C/C) genotype is the protective factor compared to the A/A genotype (0.005, OR=0.79; 95% CI: 0.68-0.93). For rs2237897, the C/T-T/T genotype is the protective factor compared to the C/C genotype (0.001, OR=0.74; 95% CI: 0.63-0.87). Furthermore, when compared with the rs2237897 (C/T-T/T) genotype, rs2237897C/C genotype showed higher HbA1C levels (8.731±2.697 vs 9.282±2.921, 0.001). Our results revealed that genetic variations in and were associated with T2DM susceptibility in a Chinese population.

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