Insulin Resistance is Associated with Gut Permeability Without the Direct Influence of Obesity in Young Adults

Overview

Journal Diabetes Metab Syndr Obes

Publisher Dove Medical Press

Specialty Endocrinology

Date 2020 Sep 14

PMID 32922055

Citations 13

Authors

Lusikelelwe Mkumbuzi

Mvuyisi M O Mfengu

Godwill A Engwa

Constance R Sewani-Rusike

Affiliations

Soon will be listed here.

Abstract

Objective: Recent findings have associated insulin resistance and obesity with increased gut permeability. However, it still remains unclear whether obesity may be the underlining factor for the association between gut permeability and insulin resistance. This study investigated the relationship between gut permeability, measures of obesity, and markers of insulin resistance in young adults.

Materials And Methods: A cross-sectional quantitative study which enrolled 151 young South African adults was conducted. Anthropometric measurements were performed to assess obesity. Adiponectin, leptin, and zonulin, a marker for gut permeability, were assayed. Insulin and fasting glucose were assayed and used to determine insulin resistance (HOMA-IR), insulin sensitivity (%S) and beta cell function (%B).

Results: Decreased adiponectin and increased leptin were associated (<0.05) with obesity. HOMA-IR inversely correlated (<0.05) with adiponectin but positively with leptin to adiponectin (Lept/ADP) ratio (<0.05) in females. Markers of insulin resistance were not associated (>0.05) with obesity. Overweight/obese (O/O) females had a significantly (<0.01) higher zonulin concentration than lean females. Zonulin positively associated (<0.05) with body mass index and visceral fat, as well as with HOMA-IR and insulin concentration. Lept/ADP ratio, an inflammatory marker, was associated with risk of insulin resistance. Increased insulin, a maker for insulin resistance, was associated with risk of gut permeability.

Conclusion: Insulin resistance was associated with gut permeability without a direct influence by obesity in young adults. The lack of relationship between obesity and insulin resistance was possibly mediated by the contribution of obesity to gut permeability. This finding suggests that gut permeability may be a potential independent risk factor for the development of insulin resistance in healthy obese young adults.

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References

Coelho M, Oliveira T, Fernandes R . Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci. 2013; 9(2):191-200. PMC: 3648822. DOI: 10.5114/aoms.2013.33181. View

Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, Rittig K . Identification and characterization of metabolically benign obesity in humans. Arch Intern Med. 2008; 168(15):1609-16. DOI: 10.1001/archinte.168.15.1609. View

Rudnicki M, Abdifarkosh G, Rezvan O, Nwadozi E, Roudier E, Haas T . Female Mice Have Higher Angiogenesis in Perigonadal Adipose Tissue Than Males in Response to High-Fat Diet. Front Physiol. 2018; 9:1452. PMC: 6206240. DOI: 10.3389/fphys.2018.01452. View

Francisco V, Pino J, Campos-Cabaleiro V, Ruiz-Fernandez C, Mera A, Gonzalez-Gay M . Obesity, Fat Mass and Immune System: Role for Leptin. Front Physiol. 2018; 9:640. PMC: 5992476. DOI: 10.3389/fphys.2018.00640. View

Kang Y, Kim J, Joung K, Lee J, You B, Choi M . The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction. PLoS One. 2016; 11(4):e0154003. PMC: 4839620. DOI: 10.1371/journal.pone.0154003. View

Wu Y, Ding Y, Tanaka Y, Zhang W . Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci. 2014; 11(11):1185-200. PMC: 4166864. DOI: 10.7150/ijms.10001. View

Ohlsson B, Orho-Melander M, Nilsson P . Higher Levels of Serum Zonulin May Rather Be Associated with Increased Risk of Obesity and Hyperlipidemia, Than with Gastrointestinal Symptoms or Disease Manifestations. Int J Mol Sci. 2017; 18(3). PMC: 5372598. DOI: 10.3390/ijms18030582. View

Johnson W . Healthy obesity: time to give up the ghost?. Ann Hum Biol. 2018; 45(4):297-298. PMC: 6191884. DOI: 10.1080/03014460.2018.1444789. View

Eltom M, Babiker Mohamed A, Elrayah-Eliadarous H, Yassin K, Noor S, Elmadhoun W . Increasing prevalence of type 2 diabetes mellitus and impact of ethnicity in north Sudan. Diabetes Res Clin Pract. 2017; 136:93-99. DOI: 10.1016/j.diabres.2017.11.034. View

10.

Gariballa S, Alkaabi J, Yasin J, Al Essa A . Total adiponectin in overweight and obese subjects and its response to visceral fat loss. BMC Endocr Disord. 2019; 19(1):55. PMC: 6545728. DOI: 10.1186/s12902-019-0386-z. View

11.

Karakelides H, Irving B, Short K, OBrien P, Nair K . Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes. 2009; 59(1):89-97. PMC: 2797949. DOI: 10.2337/db09-0591. View

12.

Forny-Germano L, De Felice F, Vieira M . The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease. Front Neurosci. 2019; 12:1027. PMC: 6340072. DOI: 10.3389/fnins.2018.01027. View

13.

Salvo Romero E, Alonso Cotoner C, Pardo Camacho C, Casado Bedmar M, Vicario M . The intestinal barrier function and its involvement in digestive disease. Rev Esp Enferm Dig. 2015; 107(11):686-96. DOI: 10.17235/reed.2015.3846/2015. View

14.

Calori G, Lattuada G, Piemonti L, Garancini M, Ragogna F, Villa M . Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study. Diabetes Care. 2010; 34(1):210-5. PMC: 3005463. DOI: 10.2337/dc10-0665. View

15.

Jung U, Choi M . Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci. 2014; 15(4):6184-223. PMC: 4013623. DOI: 10.3390/ijms15046184. View

16.

Amar J, Chabo C, Waget A, Klopp P, Vachoux C, Bermudez-Humaran L . Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med. 2011; 3(9):559-72. PMC: 3265717. DOI: 10.1002/emmm.201100159. View

17.

Saad M, Santos A, Prada P . Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. Physiology (Bethesda). 2016; 31(4):283-93. DOI: 10.1152/physiol.00041.2015. View

18.

Gutierrez-Rodelo C, Roura-Guiberna A, Olivares-Reyes J . [Molecular Mechanisms of Insulin Resistance: An Update]. Gac Med Mex. 2017; 153(2):214-228. View

19.

Samuel V, Shulman G . The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest. 2016; 126(1):12-22. PMC: 4701542. DOI: 10.1172/JCI77812. View

20.

Anhe F, Roy D, Pilon G, Dudonne S, Matamoros S, Varin T . A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut. 2014; 64(6):872-83. DOI: 10.1136/gutjnl-2014-307142. View