Does Depression Increase the Risk of Dementia? Updated Meta-analysis of Prospective Studies

Overview

Journal Actas Esp Psiquiatr

Specialty Psychiatry

Date 2020 Sep 13

PMID 32920782

Citations 6

Authors

Javier Santabarbara

Beatriz Villagrasa

Patricia Gracia-Garcia

Affiliations

Soon will be listed here.

Abstract

Background: Our primary aim was to conduct an update meta-analysis of prospective studies investigating the association between depression and dementia risk.

Methods: We searched Pubmed database to identify all relevant papers published from January 2014 to March 2019. Prospective studies with a minimum follow-up period of 1 year, baseline depression assessment, absence of dementia or mild cognitive impairment at baseline were selected. We calculated pooled relative risks (RR), with a random effect model, as well as compute population attributable fraction (PAF) of dementia due to depression.

Results: Eight cohorts were included. A statistically significant association between depression and dementia risk, with a pooled RR of 1.63 (95% CI: 1.30-2.04), and a PAF of 9.0% (95% CI: 4.5%-14.1%), were found.

Conclusions: Depression is associated with an increased risk of dementia in this meta-analysis.

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Almeida-Meza P, Steptoe A, Cadar D J Alzheimers Dis. 2021; 80(2):555-565.

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