Prediagnostic Circulating Concentrations of Vitamin D Binding Protein and Survival Among Patients with Colorectal Cancer

Overview

Journal Cancer Epidemiol Biomarkers Prev

Specialties Biochemistry
Oncology
Public Health

Date 2020 Sep 12

PMID 32917664

Citations 7

Authors

Chen Yuan

Mingyang Song

Yin Zhang

Brian M Wolpin

Jeffrey A Meyerhardt

Shuji Ogino

Bruce W Hollis

Andrew T Chan

Charles S Fuchs

Kana Wu

Molin Wang

Stephanie A Smith-Warner

Edward L Giovannucci

Kimmie Ng

Affiliations

Soon will be listed here.

Abstract

Background: Higher total 25-hydroxyvitamin D [25(OH)D] levels are associated with improved survival among patients with colorectal cancer, but the relationships between circulating vitamin D binding protein (VDBP), and bioavailable or free 25(OH)D, and colorectal cancer survival remain unknown.

Methods: We examined the associations between prediagnostic plasma levels of vitamin D-related markers and survival among 603 White participants diagnosed with colorectal cancer from two prospective U.S. cohorts. Plasma VDBP and total 25(OH)D were directly measured, while bioavailable and free 25(OH)D was calculated using a validated formula on the basis of total 25(OH)D, VDBP, and albumin levels. Cox proportional hazards regression was used to estimate HRs for overall and colorectal cancer-specific mortality, with adjustment for other prognostic markers and potential confounders.

Results: Higher VDBP levels were associated with improved overall ( = 0.001) and colorectal cancer-specific survival ( = 0.02). Compared with patients in the lowest quartile, those in the highest quartile of VDBP had a multivariate HR of 0.58 [95% confidence interval (CI), 0.41-0.80] for overall mortality and 0.58 (95% CI, 0.37-0.91) for colorectal cancer-specific mortality. The results remained similar after further adjustment for total 25(OH)D levels. In contrast, neither bioavailable nor free 25(OH)D levels were associated with overall or colorectal cancer-specific mortality (all > 0.15).

Conclusions: Prediagnostic circulating concentrations of VDBP were positively associated with survival among patients with colorectal cancer.

Impact: The clinical utility of VDBP as a prognostic marker warrants further exploration, as well as research into underlying mechanisms of action.

Citing Articles

Lack of Association Between BsmI and FokI Polymorphisms of the VDR Gene and Sporadic Colorectal Cancer in a Romanian Cohort-A Preliminary Study.

Petre-Mandache B, Burada E, Cucu M, Atasie D, Riza A, Streata I Curr Oncol. 2024; 31(10):6406-6418.

PMID: 39451780 PMC: 11505952. DOI: 10.3390/curroncol31100476.

Vitamin D Binding Protein and Postsurgical Outcomes and Tissue Injury Markers After Hip Fracture: A Prospective Study.

Meng L, Wang X, Carson J, Schlussel Y, Shapses S J Clin Endocrinol Metab. 2023; 109(1):e18-e24.

PMID: 37633261 PMC: 10735285. DOI: 10.1210/clinem/dgad502.

Prediagnostic Vitamin D Status and Colorectal Cancer Survival by Vitamin D Binding Protein Isoforms in US Cohorts.

Kim H, Yuan C, Nguyen L, Ng K, Giovannucci E J Clin Endocrinol Metab. 2022; 108(6):e223-e229.

PMID: 36550068 PMC: 10188303. DOI: 10.1210/clinem/dgac742.

Vitamin D-Binding Protein, Bioavailable, and Free 25(OH)D, and Mortality: A Systematic Review and Meta-Analysis.

Zhu A, Kuznia S, Boakye D, Schottker B, Brenner H Nutrients. 2022; 14(19).

PMID: 36235547 PMC: 9571577. DOI: 10.3390/nu14193894.

Associations between serum vitamin D biomarkers and tumor expression of Ki67, p53, and COX-2 in colorectal cancer cases from the Southern Community Cohort Study.

Lawler T, Su T, Cai Q, Steinwandel M, Zheng W, Blot W J Steroid Biochem Mol Biol. 2022; 225:106201.

PMID: 36210028 PMC: 9993486. DOI: 10.1016/j.jsbmb.2022.106201.

References

Ng K, Meyerhardt J, Wu K, Feskanich D, Hollis B, Giovannucci E . Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer. J Clin Oncol. 2008; 26(18):2984-91. DOI: 10.1200/JCO.2007.15.1027. View

Song M, Konijeti G, Yuan C, Ananthakrishnan A, Ogino S, Fuchs C . Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study. Cancer Prev Res (Phila). 2016; 9(8):664-72. PMC: 4970876. DOI: 10.1158/1940-6207.CAPR-16-0053. View

Vandewalle B, Adenis A, Hornez L, Revillion F, Lefebvre J . 1,25-dihydroxyvitamin D3 receptors in normal and malignant human colorectal tissues. Cancer Lett. 1994; 86(1):67-73. DOI: 10.1016/0304-3835(94)90181-3. View

Mezawa H, Sugiura T, Watanabe M, Norizoe C, Takahashi D, Shimojima A . Serum vitamin D levels and survival of patients with colorectal cancer: post-hoc analysis of a prospective cohort study. BMC Cancer. 2010; 10:347. PMC: 2912865. DOI: 10.1186/1471-2407-10-347. View

Kisker O, Onizuka S, Becker C, Fannon M, Flynn E, DAmato R . Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice. Neoplasia. 2003; 5(1):32-40. PMC: 1502120. DOI: 10.1016/s1476-5586(03)80015-5. View

Zehnder D, Bland R, Williams M, McNinch R, Howie A, Stewart P . Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 2001; 86(2):888-94. DOI: 10.1210/jcem.86.2.7220. View

Bissonnette M, Skarosi S, Abraham C, Brasitus T . A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. Endocrinology. 2000; 141(11):3931-9. DOI: 10.1210/endo.141.11.7782. View

Chishimba L, Thickett D, Stockley R, Wood A . The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax. 2010; 65(5):456-62. DOI: 10.1136/thx.2009.128793. View

Boutin B, Galbraith R, Arnaud P . Comparative affinity of the major genetic variants of human group-specific component (vitamin D-binding protein) for 25-(OH) vitamin D. J Steroid Biochem. 1989; 32(1A):59-63. DOI: 10.1016/0022-4731(89)90014-9. View

10.

Anic G, Weinstein S, Mondul A, Mannisto S, Albanes D . Serum vitamin D, vitamin D binding protein, and risk of colorectal cancer. PLoS One. 2014; 9(7):e102966. PMC: 4103858. DOI: 10.1371/journal.pone.0102966. View

11.

Hollis B . Quantitation of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D by radioimmunoassay using radioiodinated tracers. Methods Enzymol. 1997; 282:174-86. DOI: 10.1016/s0076-6879(97)82106-4. View

12.

Evans S, Shchepotin E, Young H, Rochon J, Uskokovic M, Shchepotin I . 1,25-dihydroxyvitamin D3 synthetic analogs inhibit spontaneous metastases in a 1,2-dimethylhydrazine-induced colon carcinogenesis model. Int J Oncol. 2000; 16(6):1249-54. DOI: 10.3892/ijo.16.6.1249. View

13.

Weinstein S, Purdue M, Smith-Warner S, Mondul A, Black A, Ahn J . Serum 25-hydroxyvitamin D, vitamin D binding protein and risk of colorectal cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Int J Cancer. 2014; 136(6):E654-64. PMC: 4289432. DOI: 10.1002/ijc.29157. View

14.

Fedirko V, Riboli E, Tjonneland A, Ferrari P, Olsen A, Bueno-de-Mesquita H . Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations. Cancer Epidemiol Biomarkers Prev. 2012; 21(4):582-93. PMC: 3378514. DOI: 10.1158/1055-9965.EPI-11-1065. View

15.

Giovannucci E, Liu Y, Rimm E, Hollis B, Fuchs C, Stampfer M . Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006; 98(7):451-9. DOI: 10.1093/jnci/djj101. View

16.

Bouillon R, Van Baelen H, DE MOOR P . Comparative study of the affinity of the serum vitamin D-binding protein. J Steroid Biochem. 1980; 13(9):1029-34. DOI: 10.1016/0022-4731(80)90133-8. View

17.

Zgaga L, Theodoratou E, Farrington S, Din F, Ooi L, Glodzik D . Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer. J Clin Oncol. 2014; 32(23):2430-9. DOI: 10.1200/JCO.2013.54.5947. View

18.

Bikle D, Gee E, Halloran B, Kowalski M, Ryzen E, Haddad J . Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986; 63(4):954-9. DOI: 10.1210/jcem-63-4-954. View

19.

Kanda S, Mochizuki Y, Miyata Y, Kanetake H, Yamamoto N . Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesis. J Natl Cancer Inst. 2002; 94(17):1311-9. DOI: 10.1093/jnci/94.17.1311. View

20.

Speeckaert M, Huang G, Delanghe J, Taes Y . Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta. 2006; 372(1-2):33-42. DOI: 10.1016/j.cca.2006.03.011. View