Association of Impaired Fasting Glucose and Type 2 Diabetes Mellitus with Brain Volume Changes in Alzheimer's Disease Patients Analyzed by MRI: a Retrospective Study

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2020 Sep 11

PMID 32913679

Citations 3

Authors

Weiwei Wang

Leongtim Wong

Lin Shi

Yishan Luo

Zhanhua Liang

Chunbo Dong

Qingwei Song

Tieli Liu

Qing Zhang

Ailian Liu

Yanwei Miao

Jianlin Wu

Affiliations

Soon will be listed here.

Abstract

Objectives: Alzheimer's disease (AD), impaired fasting glucose (IFG), and Type 2 diabetes mellitus (T2DM) were reported associated with smaller brain volumes. Nevertheless, the association of hyperglycemia with brain volume changes in AD patients remains unclear. To investigate this issue, structural magnetic resonance imaging was used to compare brain volumes among AD patients with different fasting glucose levels.

Methods: Eighty-five AD patients were divided into three groups based on their fasting glucose level as suggested by the American Diabetes Association: normal fasting glucose group (AD_NFG, = 45), AD_IFG group ( = 15), and AD_T2DM group ( = 25). Sagittal 3D T1-weighted images were obtained to calculate the brain volume. Brain parenchyma and 33 brain structures were automatically segmented. Each regional volume was analyzed among groups. For regions with statistical significance, partial correlation analysis was used to evaluate their relationships with fasting glucose level, corrected for Mini-Mental State Examination score, age, education level, cholesterol, triglyceride, and blood pressure.

Results: Compared with the AD_IFG and AD_NFG groups, the volume of pons in AD_T2DM group was significantly smaller. Fasting glucose was negatively correlated with pontine volume.

Conclusions: T2DM may exacerbate pontine atrophy in AD patients, and fasting glucose level is associated with pontine volume.

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