Hydroxysafflor Yellow A Promotes Multiterritory Perforating Flap Survival: an Experimental Study

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2020 Sep 11

PMID 32913550

Citations 4

Authors

Chenxi Zhang

Zhenxuan Shao

Zhentai Chen

Chen Lin

Sunli Hu

Zhiling Lou

Jiafeng Li

Xuanqi Zheng

Nan Lin

Weiyang Gao

Affiliations

Soon will be listed here.

Abstract

The use of perforator flaps is a common surgical technique in wound repair. However, the area surrounding the multiterritory perforating flap often becomes necrotic due to ischemia. Hydroxysafflor yellow A (HSYA), a traditional Chinese medicine extracted from edible safflower, can be used medicinally to promote angiogenesis, inhibit apoptosis, and alleviate oxidative stress and other biological activities. Here, we investigated the effect of HSYA on perforator flap survival and its potential mechanism. Our results demonstrate that HSYA significantly improves the survival area of perforator flaps, increases blood supply, reduces tissue edema, and increases mean vascular density. HSYA treatment promotes angiogenesis and inhibits oxidative stress, apoptosis, and autophagy in perforator flaps, suggesting many potential mechanisms for flap survival.

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