Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries

Overview

Journal Cancer Manag Res

Publisher Dove Medical Press

Specialty Oncology

Date 2020 Sep 9

PMID 32904568

Citations 11

Authors

Fengcai Yan

Feng Shi

Xinbao Li

ChunKai Yu

Yulin Lin

Yan Li

Mulan Jin

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.

Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.

Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.

Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.

Citing Articles

Status of and Challenges in Therapy of Mucinous Ovarian Cancer Associated with Pseudomyxoma Peritonei Syndrome: Review of Current Options and Future Treatment Trends.

Pariza G, Mavrodin C, Potorac A, Munteanu O, Cirstoiu M Life (Basel). 2024; 14(11).

PMID: 39598188 PMC: 11595252. DOI: 10.3390/life14111390.

Pseudomyxoma peritonei arising from mature ovarian teratoma, a rare entity: Report of six cases and review of current literature.

Ha M, Jamieson A, Pickett J, McGinnis J, De Greve T Gynecol Oncol Rep. 2024; 55:101488.

PMID: 39308901 PMC: 11415951. DOI: 10.1016/j.gore.2024.101488.

Multimodal diagnostic strategies and precision medicine in mucinous ovarian carcinoma: a comprehensive approach.

Wang Y, Peng L, Ye W, Lu Y Front Oncol. 2024; 14:1391910.

PMID: 39040449 PMC: 11260671. DOI: 10.3389/fonc.2024.1391910.

Ovarian Causes of Pseudomyxoma Peritonei (PMP)-A Literature Review.

Ionescu S, Marincas M, Madge O, Dicu-Andreescu I, Chitoran E, Rotaru V Cancers (Basel). 2024; 16(8).

PMID: 38672528 PMC: 11047873. DOI: 10.3390/cancers16081446.

Rapid recurrence of a ruptured mucinous borderline ovarian tumor harboring mutation followed by progression into anaplastic carcinoma with mutation.

Yang Y, Guan Y, Xu M, Liu J Heliyon. 2022; 8(10):e10877.

PMID: 36281401 PMC: 9586857. DOI: 10.1016/j.heliyon.2022.e10877.

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