Reviewing the Recent Developments in Idiopathic Intracranial Hypertension

Overview

Journal Ophthalmol Ther

Specialty Ophthalmology

Date 2020 Sep 9

PMID 32902722

Citations 20

Authors

Jasvir Virdee

Stephanie Larcombe

Vivek Vijay

Alex J Sinclair

Margaret Dayan

Susan P Mollan

Affiliations

Soon will be listed here.

Abstract

There is increasing evidence and appreciation of idiopathic intracranial hypertension (IIH) in medicine. The pathological processes underlying raised intracranial pressure are being studied, with new insights found in both hormonal dysregulation and the metabolic neuroendocrine axis. These will potentially lead to novel therapeutic targets for IIH. The first consensus guidelines have been published on the investigation and management of adult IIH, and the International Headache Society criteria for headache attributable to IIH have been modified to reflect our evolving understanding of IIH. Randomized clinical trials have been published, and a number of studies in this disease area are ongoing.

Citing Articles

Clinical outcomes of bariatric surgery in patients with obesity and idiopathic intracranial hypertension.

Wills M, Alavi M, Aleassa E, Tu C, Wilson R, Corcelles R Surg Endosc. 2024; 39(1):425-431.

PMID: 39365468 PMC: 11666706. DOI: 10.1007/s00464-024-11254-3.

A Case Report Detailing a Rare Presentation of Idiopathic Intracranial Hypertension With Atypical Symptoms.

Tibi S, Gedda H, Haris M, Joy G, Patil S Cureus. 2024; 16(4):e59072.

PMID: 38800215 PMC: 11128264. DOI: 10.7759/cureus.59072.

Navigating the Enigma: A Comprehensive Review of Idiopathic Intracranial Hypertension.

Toshniwal S, Kinkar J, Chadha Y, Khurana K, Reddy H, Kadam A Cureus. 2024; 16(3):e56256.

PMID: 38623134 PMC: 11016992. DOI: 10.7759/cureus.56256.

Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension.

Horev A, Ben-Arie G, Zlotnik Y, Koltochnik M, Ben Chaim O, Biederko R J Clin Med. 2024; 13(6).

PMID: 38541773 PMC: 10971610. DOI: 10.3390/jcm13061547.

Determining the role of novel metabolic pathways in driving intracranial pressure reduction after weight loss.

Alimajstorovic Z, Mitchell J, Yiangou A, Hancox T, Southam A, Grech O Brain Commun. 2023; 5(5):fcad272.

PMID: 37901040 PMC: 10608960. DOI: 10.1093/braincomms/fcad272.

References

Mollan S, Mitchell J, Sinclair A . Tip of the iceberg in idiopathic intracranial hypertension. Pract Neurol. 2019; 19(2):178-179. DOI: 10.1136/practneurol-2019-002198. View

. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1):1-211. DOI: 10.1177/0333102417738202. View

Matthews Y, Dean F, Lim M, McLachlan K, Rigby A, Solanki G . Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. Arch Dis Child. 2017; 102(8):715-721. DOI: 10.1136/archdischild-2016-312238. View

Kesler A, Stolovic N, Bluednikov Y, Shohat T . The incidence of idiopathic intracranial hypertension in Israel from 2005 to 2007: results of a nationwide survey. Eur J Neurol. 2014; 21(8):1055-1059. DOI: 10.1111/ene.12442. View

Almarzouqi S, Morgan M, Lee A . Idiopathic intracranial hypertension in the Middle East: A growing concern. Saudi J Ophthalmol. 2015; 29(1):26-31. PMC: 4314590. DOI: 10.1016/j.sjopt.2014.09.013. View

Friedman D, Liu G, Digre K . Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children. Neurology. 2013; 81(13):1159-65. DOI: 10.1212/WNL.0b013e3182a55f17. View

Carta A, Bertuzzi F, Cologno D, Giorgi C, Montanari E, Tedesco S . Idiopathic intracranial hypertension (pseudotumor cerebri): descriptive epidemiology, clinical features, and visual outcome in Parma, Italy, 1990 to 1999. Eur J Ophthalmol. 2004; 14(1):48-54. DOI: 10.1177/112067210401400108. View

Wall M, McDermott M, Kieburtz K, Corbett J, Feldon S, Friedman D . Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA. 2014; 311(16):1641-51. PMC: 4362615. DOI: 10.1001/jama.2014.3312. View

Speake T, Whitwell C, Kajita H, Majid A, Brown P . Mechanisms of CSF secretion by the choroid plexus. Microsc Res Tech. 2001; 52(1):49-59. DOI: 10.1002/1097-0029(20010101)52:1<49::AID-JEMT7>3.0.CO;2-C. View

10.

Bidot S, Clough L, Saindane A, Newman N, Biousse V, Bruce B . The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension. J Neuroophthalmol. 2015; 36(2):120-5. DOI: 10.1097/WNO.0000000000000318. View

11.

Fisayo A, Bruce B, Newman N, Biousse V . Overdiagnosis of idiopathic intracranial hypertension. Neurology. 2016; 86(4):341-50. PMC: 4776085. DOI: 10.1212/WNL.0000000000002318. View

12.

Killer H, Jaggi G, Miller N, Huber A, Landolt H, Mironov A . Cerebrospinal fluid dynamics between the basal cisterns and the subarachnoid space of the optic nerve in patients with papilloedema. Br J Ophthalmol. 2010; 95(6):822-7. DOI: 10.1136/bjo.2010.189324. View

13.

Mollan S, Davies B, Silver N, Shaw S, Mallucci C, Wakerley B . Idiopathic intracranial hypertension: consensus guidelines on management. J Neurol Neurosurg Psychiatry. 2018; 89(10):1088-1100. PMC: 6166610. DOI: 10.1136/jnnp-2017-317440. View

14.

Gilbert A, Chwalisz B, Mallery R . Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension. Semin Ophthalmol. 2018; 33(1):36-41. DOI: 10.1080/08820538.2017.1353810. View

15.

McCluskey G, Doherty-Allan R, McCarron P, Loftus A, McCarron L, Mulholland D . Meta-analysis and systematic review of population-based epidemiological studies in idiopathic intracranial hypertension. Eur J Neurol. 2018; 25(10):1218-1227. DOI: 10.1111/ene.13739. View

16.

Kerty E, Heuser K, Indahl U, Berg P, Nakken S, Lien S . Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort. Acta Ophthalmol. 2011; 91(1):88-91. DOI: 10.1111/j.1755-3768.2011.02231.x. View

17.

Mollan S, Spitzer D, Nicholl D . Raised intracranial pressure in those presenting with headache. BMJ. 2018; 363:k3252. DOI: 10.1136/bmj.k3252. View

18.

Sugerman H, Felton 3rd W, Salvant Jr J, Sismanis A, KELLUM J . Effects of surgically induced weight loss on idiopathic intracranial hypertension in morbid obesity. Neurology. 1995; 45(9):1655-9. DOI: 10.1212/wnl.45.9.1655. View

19.

NEWBORG B . Pseudotumor cerebri treated by rice reduction diet. Arch Intern Med. 1974; 133(5):802-7. View

20.

Markey K, Mollan S, Jensen R, Sinclair A . Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions. Lancet Neurol. 2015; 15(1):78-91. DOI: 10.1016/S1474-4422(15)00298-7. View