Sonochemical Synthesis of 2'-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Sep 9

PMID 32899705

Citations 2

Authors

Genesis Lopez

Marco Mellado

Enrique Werner

Bastian Said

Patricio Godoy

Nelson Caro

Ximena Besoain

Ivan Montenegro

Alejandro Madrid

Affiliations

Soon will be listed here.

Abstract

This work reports on the synthesis of eight new 2'-hydroxy-chalcones with potential anti-phytopathogenic applications in agroindustry, among others, via Claisen-Schmidt condensation and ultrasound assisted reaction. Assays showed three chalcones with allyl moieties strongly inhibited growth of phytopathogenic oomycete ; moreover, compound had a half maximal effective concentration (EC) value (32.5 µg/mL) similar to that of metalaxyl (28.6 µg/mL). A software-aided quantitative structure-activity relationship (QSAR) analysis of the whole series suggests that the structural features of these new chalcones-namely, the fluoride, hydroxyl, and amine groups over the carbon 3' of the chalcone skeleton-increase anti-oomycete activity.

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