Gut Microbiota Between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 Sep 9

PMID 32899315

Citations 9

Authors

Agostino Di Ciaula

Alessandro Stella

Leonilde Bonfrate

David Q H Wang

Piero Portincasa

Affiliations

Soon will be listed here.

Abstract

The gastrointestinal tract hosts the natural reservoir of microbiota since birth. The microbiota includes various bacteria that establish a progressively mutual relationship with the host. Of note, the composition of gut microbiota is rather individual-specific and, normally, depends on both the host genotype and environmental factors. The study of the bacterial profile in the gut demonstrates that dominant and minor phyla are present in the gastrointestinal tract with bacterial density gradually increasing in oro-aboral direction. The cross-talk between bacteria and host within the gut strongly contributes to the host metabolism, to structural and protective functions. Dysbiosis can develop following aging, diseases, inflammatory status, and antibiotic therapy. Growing evidences show a possible link between the microbiota and Familial Mediterranean Fever (FMF), through a shift of the relative abundance in microbial species. To which extent such perturbations of the microbiota are relevant in driving the phenotypic manifestations of FMF with respect to genetic background, remains to be further investigated.

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