Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2020 Sep 9

PMID 32899172

Citations 6

Authors

Emilia Pascale

Giuseppina Divisato

Renata Palladino

Margherita Auriemma

Edward Faustine Ngalya

Massimiliano Caiazzo

Affiliations

Soon will be listed here.

Abstract

Midbrain dopamine neurons have crucial functions in motor and emotional control and their degeneration leads to several neurological dysfunctions such as Parkinson's disease, addiction, depression, schizophrenia, and others. Despite advances in the understanding of specific altered proteins and coding genes, little is known about cumulative changes in the transcriptional landscape of noncoding genes in midbrain dopamine neurons. Noncoding RNAs-specifically microRNAs and long noncoding RNAs-are emerging as crucial post-transcriptional regulators of gene expression in the brain. The identification of noncoding RNA networks underlying all stages of dopamine neuron development and plasticity is an essential step to deeply understand their physiological role and also their involvement in the etiology of dopaminergic diseases. Here, we provide an update about noncoding RNAs involved in dopaminergic development and metabolism, and the related evidence of these biomolecules for applications in potential treatments for dopaminergic neurodegeneration.

Citing Articles

Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development.

Rybiczka-Tesulov M, Garritsen O, Veno M, Wieg L, Dijk R, Rahimi K Nat Commun. 2024; 15(1):6773.

PMID: 39117691 PMC: 11310423. DOI: 10.1038/s41467-024-51041-1.

Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern to Promote Neural Impairment in MPTP Model of Parkinson's Disease.

Zhong C, Zhang Q, Bao H, Li Y, Nie C Appl Biochem Biotechnol. 2023; 196(7):4008-4023.

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Dark DNA and stress (Review).

Malliari K, Papakonstantinou E, Mitsis T, Papageorgiou L, Pierouli K, Diakou I Int J Mol Med. 2022; 51(1).

PMID: 36484387 PMC: 9747203. DOI: 10.3892/ijmm.2022.5211.

MicroRNA Roles in Cell Reprogramming Mechanisms.

Pascale E, Caiazza C, Paladino M, Parisi S, Passaro F, Caiazzo M Cells. 2022; 11(6).

PMID: 35326391 PMC: 8946776. DOI: 10.3390/cells11060940.

MicroRNAs and Stem-like Properties: The Complex Regulation Underlying Stemness Maintenance and Cancer Development.

Divisato G, Piscitelli S, Elia M, Cascone E, Parisi S Biomolecules. 2021; 11(8).

PMID: 34439740 PMC: 8393604. DOI: 10.3390/biom11081074.

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