Microbiota-immune System Interactions and Enteric Virus Infection

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2020 Sep 8

PMID 32898729

Citations 5

Authors

Mikal A Woods Acevedo

Julie K Pfeiffer

Affiliations

Soon will be listed here.

Abstract

Enteric viruses are important human pathogens that pose a significant global health problem. These viruses infect the gastrointestinal tract, which contains a community of microbes called the 'microbiota'. We and others have shown that intestinal microbiota are crucial for the replication, pathogenesis, and transmission of a variety of enteric viruses. However, the mechanisms underlying microbiota enhancement of enteric virus infection remain unclear. Interestingly, the host immune system is dependent on both the abundance and composition of the intestinal microbiota. Here we review several aspects of how microbiota influence the immune system and how this could potentially impact enteric virus infection.

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References

Kim M, Kang S, Park J, Yanagisawa M, Kim C . Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology. 2013; 145(2):396-406.e1-10. DOI: 10.1053/j.gastro.2013.04.056. View

von Engelhardt W, Bartels J, Kirschberger S, Meyer zu Duttingdorf H, Busche R . Role of short-chain fatty acids in the hind gut. Vet Q. 1998; 20 Suppl 3:S52-9. View

Shakespear M, Halili M, Irvine K, Fairlie D, Sweet M . Histone deacetylases as regulators of inflammation and immunity. Trends Immunol. 2011; 32(7):335-43. DOI: 10.1016/j.it.2011.04.001. View

Ochoa-Reparaz J, Mielcarz D, Ditrio L, Burroughs A, Foureau D, Haque-Begum S . Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J Immunol. 2009; 183(10):6041-50. DOI: 10.4049/jimmunol.0900747. View

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P . Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 504(7480):451-5. PMC: 3869884. DOI: 10.1038/nature12726. View

Thaiss C, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, Tengeler A . Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell. 2014; 159(3):514-29. DOI: 10.1016/j.cell.2014.09.048. View

Robinson C, Woods Acevedo M, McCune B, Pfeiffer J . Related Enteric Viruses Have Different Requirements for Host Microbiota in Mice. J Virol. 2019; 93(23). PMC: 6854509. DOI: 10.1128/JVI.01339-19. View

Ekmekciu I, von Klitzing E, Fiebiger U, Escher U, Neumann C, Bacher P . Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice. Front Immunol. 2017; 8:397. PMC: 5395657. DOI: 10.3389/fimmu.2017.00397. View

Hooper L, Littman D, Macpherson A . Interactions between the microbiota and the immune system. Science. 2012; 336(6086):1268-73. PMC: 4420145. DOI: 10.1126/science.1223490. View

10.

Furusawa Y, Obata Y, Fukuda S, Endo T, Nakato G, Takahashi D . Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013; 504(7480):446-50. DOI: 10.1038/nature12721. View

11.

Lynch S, Pedersen O . The Human Intestinal Microbiome in Health and Disease. N Engl J Med. 2016; 375(24):2369-2379. DOI: 10.1056/NEJMra1600266. View

12.

Ivanov I, de Llanos Frutos R, Manel N, Yoshinaga K, Rifkin D, Sartor R . Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008; 4(4):337-49. PMC: 2597589. DOI: 10.1016/j.chom.2008.09.009. View

13.

Kelly C, Zheng L, Campbell E, Saeedi B, Scholz C, Bayless A . Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015; 17(5):662-71. PMC: 4433427. DOI: 10.1016/j.chom.2015.03.005. View

14.

Chang P, Hao L, Offermanns S, Medzhitov R . The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2014; 111(6):2247-52. PMC: 3926023. DOI: 10.1073/pnas.1322269111. View

15.

Grau K, Zhu S, Peterson S, Helm E, Philip D, Phillips M . The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon. Nat Microbiol. 2019; 5(1):84-92. PMC: 6925324. DOI: 10.1038/s41564-019-0602-7. View

16.

Woods Acevedo M, Pfeiffer J . Microbiota-independent antiviral effects of antibiotics on poliovirus and coxsackievirus. Virology. 2020; 546:20-24. PMC: 7253499. DOI: 10.1016/j.virol.2020.04.001. View

17.

Kuster K, Grotzinger C, Koschel A, Fischer A, Wiedenmann B, Anders M . Sodium butyrate increases expression of the coxsackie and adenovirus receptor in colon cancer cells. Cancer Invest. 2009; 28(3):268-74. DOI: 10.3109/07357900902783195. View

18.

Kaiko G, Ryu S, Koues O, Collins P, Solnica-Krezel L, Pearce E . The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Cell. 2016; 167(4):1137. DOI: 10.1016/j.cell.2016.10.034. View

19.

Kane M, Case L, Kopaskie K, Kozlova A, MacDearmid C, Chervonsky A . Successful transmission of a retrovirus depends on the commensal microbiota. Science. 2011; 334(6053):245-9. PMC: 3519937. DOI: 10.1126/science.1210718. View

20.

Kilic T, Koromyslova A, Hansman G . Structural Basis for Human Norovirus Capsid Binding to Bile Acids. J Virol. 2018; 93(2). PMC: 6321941. DOI: 10.1128/JVI.01581-18. View