Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Overview

Journal Bioengineering (Basel)

Date 2020 Sep 5

PMID 32887327

Citations 30

Authors

Pasquale Marrazzo

Cian OLeary

Affiliations

Soon will be listed here.

Abstract

Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

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