Transforming Growth Factor Beta Signaling Functions During Mammalian Kidney Development

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2020 Sep 4

PMID 32880018

Citations 8

Authors

Mihai G Dumbrava

Jon L Lacanlale

Christopher J Rowan

Norman D Rosenblum

Affiliations

Soon will be listed here.

Abstract

Aberrant transforming growth factor beta (TGFβ) signaling during embryogenesis is implicated in severe congenital abnormalities, including kidney malformations. However, the molecular mechanisms that underlie congenital kidney malformations related to TGFβ signaling remain poorly understood. Here, we review current understanding of the lineage-specific roles of TGFβ signaling during kidney development and how dysregulation of TGFβ signaling contributes to the pathogenesis of kidney malformation.

Citing Articles

Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis.

Davis S, Grindel S, Viola J, Liu G, Liu J, Qian G bioRxiv. 2023; .

PMID: 38045273 PMC: 10690271. DOI: 10.1101/2023.11.21.568157.

Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches.

Viola J, Liu J, Huang A, Grindel S, Prahl L, Hughes A bioRxiv. 2023; .

PMID: 37986773 PMC: 10659296. DOI: 10.1101/2023.11.08.566308.

Genetic and environmental factors driving congenital solitary functioning kidney.

Groen In t Woud S, van Gelder M, van Rooij I, Feitz W, Roeleveld N, Schreuder M Nephrol Dial Transplant. 2023; 39(3):463-472.

PMID: 37738450 PMC: 10899751. DOI: 10.1093/ndt/gfad202.

Genomic organization, intragenic tandem duplication, and expression analysis of chicken TGFBR2 gene.

Ning B, Huang J, Xu H, Lou Y, Wang W, Mu F Poult Sci. 2022; 101(12):102169.

PMID: 36201879 PMC: 9535321. DOI: 10.1016/j.psj.2022.102169.

The origin and role of the renal stroma.

Wilson S, Little M Development. 2021; 148(19).

PMID: 34553766 PMC: 8497777. DOI: 10.1242/dev.199886.

References

Scott R, Quaggin S . Review series: The cell biology of renal filtration. J Cell Biol. 2015; 209(2):199-210. PMC: 4411276. DOI: 10.1083/jcb.201410017. View

McMahon A . Development of the Mammalian Kidney. Curr Top Dev Biol. 2016; 117:31-64. PMC: 5007134. DOI: 10.1016/bs.ctdb.2015.10.010. View

Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H . Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell. 2013; 14(1):53-67. DOI: 10.1016/j.stem.2013.11.010. View

Little M, Combes A, Takasato M . Understanding kidney morphogenesis to guide renal tissue regeneration. Nat Rev Nephrol. 2016; 12(10):624-35. DOI: 10.1038/nrneph.2016.126. View

Blake J, Rosenblum N . Renal branching morphogenesis: morphogenetic and signaling mechanisms. Semin Cell Dev Biol. 2014; 36:2-12. DOI: 10.1016/j.semcdb.2014.07.011. View

Costantini F, Kopan R . Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell. 2010; 18(5):698-712. PMC: 2883254. DOI: 10.1016/j.devcel.2010.04.008. View

Mugford J, Sipila P, McMahon J, McMahon A . Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol. 2008; 324(1):88-98. PMC: 2642884. DOI: 10.1016/j.ydbio.2008.09.010. View

Kobayashi A, Valerius M, Mugford J, Carroll T, Self M, Oliver G . Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008; 3(2):169-81. PMC: 2561900. DOI: 10.1016/j.stem.2008.05.020. View

Kobayashi A, Mugford J, Krautzberger A, Naiman N, Liao J, McMahon A . Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis. Stem Cell Reports. 2014; 3(4):650-62. PMC: 4223698. DOI: 10.1016/j.stemcr.2014.08.008. View

10.

OBrien L, McMahon A . Induction and patterning of the metanephric nephron. Semin Cell Dev Biol. 2014; 36:31-8. PMC: 4252735. DOI: 10.1016/j.semcdb.2014.08.014. View

11.

Li W, Hartwig S, Rosenblum N . Developmental origins and functions of stromal cells in the normal and diseased mammalian kidney. Dev Dyn. 2014; 243(7):853-63. DOI: 10.1002/dvdy.24134. View

12.

Descargues P, Sil A, Sano Y, Korchynskyi O, Han G, Owens P . IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A. 2008; 105(7):2487-92. PMC: 2268163. DOI: 10.1073/pnas.0712044105. View

13.

Muraoka R, Dumont N, Ritter C, Dugger T, Brantley D, Chen J . Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest. 2002; 109(12):1551-9. PMC: 151012. DOI: 10.1172/JCI15234. View

14.

Tomlinson D, Freestone S, Grace O, Thomson A . Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate. Endocrinology. 2004; 145(9):4292-300. DOI: 10.1210/en.2004-0526. View

15.

Dickson M, Martin J, Cousins F, Kulkarni A, Karlsson S, Akhurst R . Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development. 1995; 121(6):1845-54. DOI: 10.1242/dev.121.6.1845. View

16.

Oshima M, Oshima H, Taketo M . TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol. 1996; 179(1):297-302. DOI: 10.1006/dbio.1996.0259. View

17.

Azhar M, Schultz J, Grupp I, Dorn 2nd G, Meneton P, Molin D . Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev. 2003; 14(5):391-407. PMC: 3855389. DOI: 10.1016/s1359-6101(03)00044-3. View

18.

Shull M, Ormsby I, Kier A, Pawlowski S, Diebold R, Yin M . Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 1992; 359(6397):693-9. PMC: 3889166. DOI: 10.1038/359693a0. View

19.

Kulkarni A, Huh C, Becker D, Geiser A, Lyght M, Flanders K . Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993; 90(2):770-4. PMC: 45747. DOI: 10.1073/pnas.90.2.770. View

20.

Oxburgh L, Chu G, Michael S, Robertson E . TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004; 131(18):4593-605. DOI: 10.1242/dev.01324. View