Role of Inflammasomes in Multiple Sclerosis and Their Potential As Therapeutic Targets

Overview

Journal J Neuroinflammation

Publisher Biomed Central

Date 2020 Sep 4

PMID 32878648

Citations 47

Authors

Vaidya Govindarajan

Juan Pablo de Rivero Vaccari

Robert W Keane

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS. While the cause of MS is unclear, the underlying pathomechanisms are thought to be either destruction by autoimmune T cells or dysfunction of myelin-producing cells. Recent advances have indicated that inflammasomes contribute the etiology of MS. Inflammasomes are multiprotein complexes of the innate immune response involved in the processing of caspase-1, the activation of pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as the cell death-mediated mechanism of pyroptosis and the activation of the adaptive immune response. Here we review the literature to date on the role of different inflammasome signaling pathways in the pathogenesis of MS and how these pathways may be targeted to reduce deleterious inflammatory processes and improve outcomes in this patient population.

Citing Articles

Mitochondrial dysfunction, iron accumulation, lipid peroxidation, and inflammasome activation in cellular models derived from patients with multiple sclerosis.

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Comparison of Methods of Detecting IL-1β in the Blood of Alzheimer's Disease Subjects.

Remnitz A, Hadad R, Keane R, Dietrich W, de Rivero Vaccari J Int J Mol Sci. 2025; 26(2).

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Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy.

Xu Y, Chen Y, Xing J, Yao J Clin Epigenetics. 2025; 17(1):13.

PMID: 39849536 PMC: 11761206. DOI: 10.1186/s13148-025-01820-4.

Pyroptosis the Emerging Link Between Gut Microbiota and Multiple Sclerosis.

Fan H, Shen R, Yan J, Bai Y, Fu Q, Shi X Drug Des Devel Ther. 2024; 18:6145-6164.

PMID: 39717200 PMC: 11665440. DOI: 10.2147/DDDT.S489454.

Microglial Mayhem NLRP3 Inflammasome's Role in Multiple Sclerosis Pathology.

Fan H, Fu Q, Du G, Qin L, Shi X, Wang D CNS Neurosci Ther. 2024; 30(12):e70135.

PMID: 39690733 PMC: 11652677. DOI: 10.1111/cns.70135.

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