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Stability, Homogeneity and Carry-Over of Amoxicillin, Doxycycline, Florfenicol and Flubendazole in Medicated Feed and Drinking Water on 24 Pig Farms

Overview
Specialty Pharmacology
Date 2020 Sep 4
PMID 32878274
Citations 6
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Abstract

The vast majority of medicines in pig rearing are administered via oral group medication through medicated feed and drinking water. However, relevant on-farm factors affecting the concentration of these drugs in feed and drinking water, such as the homogeneity, stability, and cross-contamination, are largely unknown. To characterize these factors, samples of medicated feed and drinking water were taken on 24 Belgian pig farms during treatment and 2 days thereafter, as well as at different on-farm sampling sites from production to feeding troughs or drinking nipples. The samples contained amoxicillin, doxycycline, florfenicol, or flubendazole. Additionally, a questionnaire was completed. In contrast to the results of medicated feed, results of medicated water showed a large between-farm variation in antimicrobial drug concentration. The therapeutic concentration range was only met in 2 out of 11 farms using medicated feed, and in 3 out of 13 farms using medicated water. Medicated feed concentrations were often below the therapeutic concentration range mentioned in the Summary of Product Characteristics, while drinking water concentrations were just as often above as they were below the advised target concentration range. Drug residues measured 2 days after the end of therapy with both feed and water medication rarely exceeded 1% of the lowest therapeutic concentration. This study demonstrates that recommendations on good clinical practices for oral group medication in the pig industry are highly needed.

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References
1.
Liu J, Fung K, Chen Z, Zeng Z, Zhang J . Pharmacokinetics of florfenicol in healthy pigs and in pigs experimentally infected with Actinobacillus pleuropneumoniae. Antimicrob Agents Chemother. 2003; 47(2):820-3. PMC: 151723. DOI: 10.1128/AAC.47.2.820-823.2003. View

2.
Backhans A, Sjolund M, Lindberg A, Emanuelson U . Biosecurity level and health management practices in 60 Swedish farrow-to-finish herds. Acta Vet Scand. 2015; 57:14. PMC: 4359795. DOI: 10.1186/s13028-015-0103-5. View

3.
Kadlec K, Kehrenberg C, Wallmann J, Schwarz S . Antimicrobial susceptibility of Bordetella bronchiseptica isolates from porcine respiratory tract infections. Antimicrob Agents Chemother. 2004; 48(12):4903-6. PMC: 529238. DOI: 10.1128/AAC.48.12.4903-4906.2004. View

4.
Filippitzi M, Sarrazin S, Imberechts H, Smet A, Dewulf J . Risk of cross-contamination due to the use of antimicrobial medicated feed throughout the trail of feed from the feed mill to the farm. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016; 33(4):644-55. DOI: 10.1080/19440049.2016.1160442. View

5.
McIntyre A, Lipman N . Amoxicillin-clavulanic acid and trimethoprim- sulfamethoxazole in rodent feed and water: effects of compounding on antibiotic stability. J Am Assoc Lab Anim Sci. 2007; 46(5):26-32. View