Immune Modulation of Platelet-Derived Mitochondria on Memory CD4 T Cells in Humans

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Sep 4

PMID 32878069

Citations 12

Authors

Haibo Yu

Wei Hu

Xiang Song

Yong Zhao

Affiliations

Soon will be listed here.

Abstract

CD4 T cells are one of the key immune cells contributing to the immunopathogenesis of type 1 diabetes (T1D). Previous studies have reported that platelet-derived mitochondria suppress the proliferation of peripheral blood mononuclear cells (PBMC). To further characterize the immune modulation of platelet-derived mitochondria, the purified CD4 T cells were treated, respectively, with platelet-derived mitochondria. The data demonstrated that MitoTracker Deep Red-labeled platelet-derived mitochondria could directly target CD4 T cells through C-X-C motif chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1 (SDF-1), regulating the anti-CD3/CD28 bead-activated CD4 T cells. The result was an up-regulation of Naïve and central memory (T) CD4 T cells, the down-regulation of effector memory (T) CD4 T cells, and modulations of cytokine productions and gene expressions. Thus, platelet-derived mitochondria have a translational potential as novel immune modulators to treat T1D and other autoimmune diseases.

Citing Articles

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Platelet mitochondria, a potent immune mediator in neurological diseases.

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