Lip Balm Drying Promotes Virus Attachment: Characterization of Lip Balm Coatings and XDLVO Modeling

Overview

Journal J Colloid Interface Sci

Specialty Chemistry

Date 2020 Sep 3

PMID 32877879

Authors

Xunhao Wang

Reyhan Sengur-Tasdemir

Ismail Koyuncu

Volodymyr V Tarabara

Affiliations

Soon will be listed here.

Abstract

Hypothesis: Drying-induced decrease in lip balm surface energy enhances virus adhesion due to the emergence of strong hydrophobic colloid-surface interactions.

Experiments: A protocol was developed for preparing lip balm coatings to enable physicochemical characterization and adhesion studies. Surface charge and hydrophobicity of four brands of lip balm (dry and hydrated) and human adenovirus 5 (HAdV5) were measured and used to calculate the extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) energy of interactions between lip balm coatings and HAdV5 as well as four other colloids: HAdV40, MS2 and P22 bacteriophages, and SiO. Quartz crystal microbalance with dissipation monitoring (QCM-D) tests employed SiO colloids, HAdV5 and hydrated lip balms.

Findings: Drying of lip balms results in a dramatic decrease of their surface energy (δΔG≥ 83.0 mJ/m) making the surfaces highly hydrophobic. For dry lip balms, the interaction of the balm surface with all five colloids is attractive. For lip balms hydrated in 150 mM NaCl (ionic strength of human saliva), XDLVO calculations predict that hydrophilic colloids (MS2, P22, SiO) may attach into shallow secondary minima. Due to the relative hydrophobicity of human adenoviruses, primary maxima in XDLVO profiles are low or non-existent making irreversible deposition into primary energy minima possible. Preliminary QCM-D tests with SiO colloids and HAdV5 confirm deposition on hydrated lip balms.

References

Julian T, Leckie J, Boehm A . Virus transfer between fingerpads and fomites. J Appl Microbiol. 2010; 109(6):1868-74. DOI: 10.1111/j.1365-2672.2010.04814.x. View

Lundov M, Zachariae C . Recalls of microbiologically contaminated cosmetics in EU from 2005 to May 2008. Int J Cosmet Sci. 2008; 30(6):471-4. DOI: 10.1111/j.1468-2494.2008.00475.x. View

Stewart S, Parker M, Amezquita A, Pitt T . Microbiological risk assessment for personal care products. Int J Cosmet Sci. 2016; 38(6):634-645. DOI: 10.1111/ics.12338. View

Gary Jr G, Hierholzer J, Black R . Characteristics of noncultivable adenoviruses associated with diarrhea in infants: a new subgroup of human adenoviruses. J Clin Microbiol. 1979; 10(1):96-103. PMC: 273101. DOI: 10.1128/jcm.10.1.96-103.1979. View

Pitol A, Bischel H, Kohn T, Julian T . Virus Transfer at the Skin-Liquid Interface. Environ Sci Technol. 2017; 51(24):14417-14425. DOI: 10.1021/acs.est.7b04949. View

Lu R, Li Q, Nguyen T . Random sequential adsorption of human adenovirus 2 onto polyvinylidene fluoride surface influenced by extracellular polymeric substances. J Colloid Interface Sci. 2016; 466:120-7. DOI: 10.1016/j.jcis.2015.12.017. View

Xing Y, Ellis A, Magnuson M, Harper Jr W . Adsorption of bacteriophage MS2 to colloids: Kinetics and particle interactions. Colloids Surf A Physicochem Eng Asp. 2022; 585:1-7. PMC: 9067426. DOI: 10.1016/j.colsurfa.2019.124099. View

Yuan B, Pham M, Nguyen T . Deposition kinetics of bacteriophage MS2 on a silica surface coated with natural organic matter in a radial stagnation point flow cell. Environ Sci Technol. 2008; 42(20):7628-33. DOI: 10.1021/es801003s. View

Wang J, Kay A, Fletcher J, Formica M, McAlindon T . Is lipstick associated with the development of systemic lupus erythematosus (SLE)?. Clin Rheumatol. 2008; 27(9):1183-7. PMC: 3645843. DOI: 10.1007/s10067-008-0937-6. View

10.

Gutierrez L, Mylon S, Nash B, Nguyen T . Deposition and aggregation kinetics of rotavirus in divalent cation solutions. Environ Sci Technol. 2010; 44(12):4552-7. DOI: 10.1021/es100120k. View

11.

Armanious A, Aeppli M, Jacak R, Refardt D, Sigstam T, Kohn T . Viruses at Solid-Water Interfaces: A Systematic Assessment of Interactions Driving Adsorption. Environ Sci Technol. 2015; 50(2):732-43. DOI: 10.1021/acs.est.5b04644. View

12.

Baliga S, Muglikar S, Kale R . Salivary pH: A diagnostic biomarker. J Indian Soc Periodontol. 2013; 17(4):461-5. PMC: 3800408. DOI: 10.4103/0972-124X.118317. View

13.

Pham M, Mintz E, Nguyen T . Deposition kinetics of bacteriophage MS2 to natural organic matter: role of divalent cations. J Colloid Interface Sci. 2009; 338(1):1-9. DOI: 10.1016/j.jcis.2009.06.025. View

14.

Dang H, Tarabara V . Virus deposition onto polyelectrolyte-coated surfaces: A study with bacteriophage MS2. J Colloid Interface Sci. 2019; 540:155-166. DOI: 10.1016/j.jcis.2018.12.107. View

15.

Stephens B, Azimi P, Thoemmes M, Heidarinejad M, Allen J, Gilbert J . Microbial Exchange via Fomites and Implications for Human Health. Curr Pollut Rep. 2021; 5(4):198-213. PMC: 7149182. DOI: 10.1007/s40726-019-00123-6. View

16.

Shi H, Tarabara V . Charge, size distribution and hydrophobicity of viruses: Effect of propagation and purification methods. J Virol Methods. 2018; 256:123-132. DOI: 10.1016/j.jviromet.2018.02.008. View

17.

Wong K, Mukherjee B, Kahler A, Zepp R, Molina M . Influence of inorganic ions on aggregation and adsorption behaviors of human adenovirus. Environ Sci Technol. 2012; 46(20):11145-53. DOI: 10.1021/es3028764. View

18.

Chen Y, Shen L, Li R, Xu X, Hong H, Lin H . Quantification of interfacial energies associated with membrane fouling in a membrane bioreactor by using BP and GRNN artificial neural networks. J Colloid Interface Sci. 2020; 565:1-10. DOI: 10.1016/j.jcis.2020.01.003. View

19.

Mbithi J, Springthorpe V, Boulet J, Sattar S . Survival of hepatitis A virus on human hands and its transfer on contact with animate and inanimate surfaces. J Clin Microbiol. 1992; 30(4):757-63. PMC: 265157. DOI: 10.1128/jcm.30.4.757-763.1992. View

20.

Ansari S, Springthorpe V, Sattar S, Rivard S, Rahman M . Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus 3 and rhinovirus 14. J Clin Microbiol. 1991; 29(10):2115-9. PMC: 270283. DOI: 10.1128/jcm.29.10.2115-2119.1991. View