Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2020 Sep 3

PMID 32877641

Citations 31

Authors

Brent Asrican

Josh Wooten

Ya-Dong Li

Luis Quintanilla

Feiran Zhang

Connor Wander

Hechen Bao

Chia-Yu Yeh

Yan-Jia Luo

Reid Olsen

Szu-Aun Lim

Jessica Hu

Peng Jin

Juan Song

Affiliations

Soon will be listed here.

Abstract

Neural stem cells (NSCs) in the dentate gyrus (DG) reside in a specialized local niche that supports their neurogenic proliferation to produce adult-born neurons throughout life. How local niche cells interact at the circuit level to ensure continuous neurogenesis from NSCs remains unknown. Here we report the role of endogenous neuropeptide cholecystokinin (CCK), released from dentate CCK interneurons, in regulating neurogenic niche cells and NSCs. Specifically, stimulating CCK release supports neurogenic proliferation of NSCs through a dominant astrocyte-mediated glutamatergic signaling cascade. In contrast, reducing dentate CCK induces reactive astrocytes, which correlates with decreased neurogenic proliferation of NSCs and upregulation of genes involved in immune processes. Our findings provide novel circuit-based information on how CCK acts on local astrocytes to regulate the key behavior of adult NSCs.

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