Roles of Gut Microbiota in Pathogenesis of Alzheimer's Disease and Therapeutic Effects of Chinese Medicine

Overview

Journal Chin J Integr Med

Date 2020 Sep 3

PMID 32876860

Citations 8

Authors

Ying-Xin Sun

Xi-Juan Jiang

Bin Lu

Qing Gao

Ye-Fei Chen

Dan-Bin Wu

Wen-Yun Zeng

Lin Yang

Hu-Hu Li

Bin Yu

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD. Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed. The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.

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